| Literature DB >> 24845382 |
Rafael Perígolo-Vicente1, Karen Ritt2, Cassiano Felippe Gonçalves-de-Albuquerque3, Hugo Caire Castro-Faria-Neto3, Roberto Paes-de-Carvalho2, Elizabeth Giestal-de-Araujo2.
Abstract
Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection after axotomy of these cells. Interleukin-6 has been shown to be able to increase the survival and regeneration of retinal ganglion cells (RGC) in mixed culture as well as in vivo. In this work we show that the trophic effect of IL-6 is mediated by adenosine receptor (A2aR) activation and also by the presence of extracellular BDNF. We also show that there is a complex cross-talk between IL-6, BDNF, the Adenosine A1 and A2a receptors that results in neuroprotection of retinal ganglion cells.Entities:
Keywords: Adenosine receptors; Axotomy; BDNF; Cell culture; Neuronal death; Retina
Mesh：
Substances：
Year: 2014 PMID： 24845382 DOI： 10.1016/j.bbrc.2014.05.036
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575