Literature DB >> 2484534

Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency.

T Günther1, E Rebentisch, J Vormann, M König, H Ising.   

Abstract

In rats, Mg deficiency caused a moderate hearing loss, measured by means of evoked potentials at 10 and 20 kHz, which was repaired after refeeding a normal diet. Application of 700 mg/kg salicylic acid or injection of 5 x 100 mg/kg gentamicin also caused a reversible hearing loss in normally fed rats. Treatment of Zn-deficient rats with salicylic acid produced a stronger although reversible hearing loss than in normally fed salicylate-treated rats. Treatment of Mg-deficient rats with gentamicin induced a strong hearing loss that was nearly complete and irreversible in 9 of 25 rats.

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Year:  1988        PMID： 2484534     DOI： 10.1007/BF02795332

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  24 in total

1.  Metabolism of salicylate by isolated kidney and liver mitochondria.

Authors:  M E Kyle; J J Kocsis
Journal:  Chem Biol Interact       Date:  1986-10-01       Impact factor: 5.192

2.  The cellular basis of hearing: the biophysics of hair cells.

Authors:  A J Hudspeth
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

3.  Free radical mechanisms in relation to tissue injury.

Authors:  T F Slater; K H Cheeseman; M J Davies; K Proudfoot; W Xin
Journal:  Proc Nutr Soc       Date:  1987-02       Impact factor: 6.297

4.  Periods of sensitivity to antibiotic treatment.

Authors:  R Pujol
Journal:  Acta Otolaryngol Suppl       Date:  1986

5.  Chemical changes in the cerebrospinal fluid and brain in magnesium deficiency.

Authors:  J G Chutkow; S Meyers
Journal:  Neurology       Date:  1968-10       Impact factor: 9.910

Review 6.  Pathophysiology and clinical aspects of drug-induced tubular necrosis in man.

Authors:  D Kleinknecht; P Landais; B Goldfarb
Journal:  Contrib Nephrol       Date:  1987       Impact factor: 1.580

7.  Vitamin, selenium, zinc and copper interactions in free radical protection against ill-placed iron.

Authors:  R L Willson
Journal:  Proc Nutr Soc       Date:  1987-02       Impact factor: 6.297

8.  The comparative ototoxicities of gentamicin, tobramycin and dibekacin in the guinea pig. A functional and morphological cochlear and vestibular study.

Authors:  J M Aran; J P Erre; A Guilhaume; C Aurousseau
Journal:  Acta Otolaryngol Suppl       Date:  1982

9.  Effect of a zinc-deficient diet on lipid peroxidation in liver and tumor subcellular membranes.

Authors:  J P Burke; M R Fenton
Journal:  Proc Soc Exp Biol Med       Date:  1985-06

10.  Failure of inhibition of lipid peroxidation by vitamin E to protect against gentamicin nephrotoxicity in the rat.

Authors:  L S Ramsammy; C Josepovitz; K Y Ling; B P Lane; G J Kaloyanides
Journal:  Biochem Pharmacol       Date:  1987-07-01       Impact factor: 5.858
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  5 in total

1.  Enhancement of gentamicin-induced nephrotoxicity by Mg deficiency in non-pregnant rats. Morphological, enzyme histochemical and immunohistochemical studies.

Authors:  R Gossrau; T Günther; R Graf
Journal:  Histochemistry       Date:  1989

2.  Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity.

Authors:  Guang-Di Chen; Mohammad Habiby Kermany; Alessandra D'Elia; Massimo Ralli; Chiemi Tanaka; Eric C Bielefeld; Dalian Ding; Donald Henderson; Richard Salvi
Journal:  Hear Res       Date:  2010-03-06       Impact factor: 3.208

3.  Lipid peroxidation in mitochondria and microsomes from adult and fetal rat tissues. Effects of Zn deficiency, Fe, and salicylate.

Authors:  T Günther; V Höllriegl
Journal:  Biol Trace Elem Res       Date:  1989-11       Impact factor: 3.738

4.  Maternal and fetal iron accumulation in Zn-deficient and salicylate-treated rats.

Authors:  T Günther; R Gossrau; J Vormann; V Höllriegl; R Graf
Journal:  Biol Trace Elem Res       Date:  1988-12       Impact factor: 3.738

5.  Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer.

Authors:  C Bokemeyer; C C Berger; J T Hartmann; C Kollmannsberger; H J Schmoll; M A Kuczyk; L Kanz
Journal:  Br J Cancer       Date:  1998-04       Impact factor: 7.640
  5 in total

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