Literature DB >> 24845031

Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer.

Xue-Lei Wang1, Xiao-Fei Wen, Rong-Bing Li, Bin Liu, Guang-Ming Qiu, Ji-Ling Wen, Yue-Min Wang.   

Abstract

Androgen receptor (AR), a member of nuclear hormone receptor, plays an essential role in the initiation and progression of prostate cancer (PCa). In the present study, by way of immunoprecipitation followed by mass spectrometry (IP/MS) system, we found that carbohydrate-responsive element-binding protein (Chrebp), a glucose sensor in normal and cancer cells, interacted with AR in LNCaP cells. The interaction was further confirmed by coimmunoprecipitation analysis. Besides, Chrebp is required for the optimal transcriptional activity of AR in promoting the transcription of the prostate-specific antigen (PSA) promoter and messenger RNA (mRNA) expression. Consistently, knockdown of Chrebp using small interfering RNA (siRNA) in LNCaP cells reduced endogenous PSA levels. Together, our study demonstrates that Chrebp interacts with AR and regulates its transcriptional activity.

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Year:  2014        PMID： 24845031     DOI： 10.1007/s13277-014-2085-8

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  20 in total

Review 1.  Prostate cancer: The androgen receptor remains front and centre.

Authors:  Philip J Saylor
Journal:  Nat Rev Clin Oncol       Date:  2013-02-05       Impact factor: 66.675

2.  A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver.

Authors:  H Yamashita; M Takenoshita; M Sakurai; R K Bruick; W J Henzel; W Shillinglaw; D Arnot; K Uyeda
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

3.  Prostate cancer-from steroid transformations to clinical translation.

Authors:  Kai-Hsiung Chang; Nima Sharifi
Journal:  Nat Rev Urol       Date:  2012-10-02       Impact factor: 14.432

4.  The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation.

Authors:  Xuemei Tong; Fangping Zhao; Anthony Mancuso; Joshua J Gruber; Craig B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-07       Impact factor: 11.205

Review 5.  Overview of the latest treatments for castration-resistant prostate cancer.

Authors:  Mohamed Bishr; Fred Saad
Journal:  Nat Rev Urol       Date:  2013-06-25       Impact factor: 14.432

6.  The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans.

Authors:  Fadila Benhamed; Pierre-Damien Denechaud; Maud Lemoine; Céline Robichon; Marthe Moldes; Justine Bertrand-Michel; Vlad Ratziu; Lawrence Serfaty; Chantal Housset; Jacqueline Capeau; Jean Girard; Hervé Guillou; Catherine Postic
Journal:  J Clin Invest       Date:  2012-05-01       Impact factor: 14.808

Review 7.  Androgen-receptor-interacting nuclear proteins.

Authors:  O A Jänne; A M Moilanen; H Poukka; N Rouleau; U Karvonen; N Kotaja; M Häkli; J J Palvimo
Journal:  Biochem Soc Trans       Date:  2000       Impact factor: 5.407

8.  Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1.

Authors:  Elin Holter; Noora Kotaja; Sari Mäkela; Leena Strauss; Silke Kietz; Olli A Jänne; Jan-Ake Gustafsson; Jorma J Palvimo; Eckardt Treuter
Journal:  Mol Endocrinol       Date:  2002-03

Review 9.  The role of estrogen and androgen receptors in bone health and disease.

Authors:  Stavros C Manolagas; Charles A O'Brien; Maria Almeida
Journal:  Nat Rev Endocrinol       Date:  2013-09-17       Impact factor: 43.330

10.  Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth.

Authors:  Maofu Fu; Mahadev Rao; Chenguang Wang; Toshiyuki Sakamaki; Jian Wang; Dolores Di Vizio; Xueping Zhang; Chris Albanese; Steven Balk; Chawnshang Chang; Saijun Fan; Eliot Rosen; Jorma J Palvimo; Olli A Jänne; Selen Muratoglu; Maria Laura Avantaggiati; Richard G Pestell
Journal:  Mol Cell Biol       Date:  2003-12       Impact factor: 4.272
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  2 in total

1.  Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinoma.

Authors:  Silvia Ribback; Li Che; Maria G Pilo; Antonio Cigliano; Gavinella Latte; Giovanni M Pes; Alberto Porcu; Rosa M Pascale; Lei Li; Yu Qiao; Frank Dombrowski; Xin Chen; Diego F Calvisi
Journal:  Cell Cycle       Date:  2018-07-18       Impact factor: 4.534

Review 2.  Analyzing the Androgen Receptor Interactome in Prostate Cancer: Implications for Therapeutic Intervention.

Authors:  Ujjwal R Dahiya; Hannelore V Heemers
Journal:  Cells       Date:  2022-03-09       Impact factor: 7.666
  2 in total

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