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Literature DB >> 24844436

Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta.

S Lager¹, V I Ramirez², F Gaccioli², T Jansson², T L Powell².

Abstract

Fatty acids can function as signaling molecules, acting through receptors in the cytosol or on the cell surface. G-Protein Receptor (GPR)120 is a membrane-bound receptor mediating anti-inflammatory and insulin-sensitizing effects of the omega-3 fatty acid docohexaenoic acid (DHA). GPR120 dysfunction is associated with obesity in humans. Cellular localization of GPR120 and the influence of maternal obesity on GPR120 protein expression in the placenta are unknown. Herein we demonstrate that GPR120 is predominantly expressed in the microvillous membrane (MVM) of human placenta and that the expression level of this receptor in MVM is not altered by maternal body mass index (BMI).

Entities: Chemical Disease Gene Species

Keywords: BMI; DHA receptor; FFAR4; O3FAR1; Pregnancy

Mesh：

Substances：

Year: 2014 PMID： 24844436 PMCID： PMC4096656 DOI： 10.1016/j.placenta.2014.04.017

Source DB: PubMed Journal: Placenta ISSN： 0143-4004 Impact factor: 3.481

15 in total

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Journal: Nat Med Date: 2004-12-26 Impact factor: 53.440

2. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways.

Authors: Irving L M H Aye; Susanne Lager; Vanessa I Ramirez; Francesca Gaccioli; Donald J Dudley; Thomas Jansson; Theresa L Powell
Journal: Biol Reprod Date: 2014-04-23 Impact factor: 4.285

3. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.

Authors: Da Young Oh; Saswata Talukdar; Eun Ju Bae; Takeshi Imamura; Hidetaka Morinaga; WuQiang Fan; Pingping Li; Wendell J Lu; Steven M Watkins; Jerrold M Olefsky
Journal: Cell Date: 2010-09-03 Impact factor: 41.582

4. Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4.

Authors: Susanne Lager; Francesca Gaccioli; Vanessa I Ramirez; Helen N Jones; Thomas Jansson; Theresa L Powell
Journal: J Lipid Res Date: 2012-12-30 Impact factor: 5.922

5. Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta.

Authors: A Ericsson; B Hamark; T L Powell; T Jansson
Journal: Hum Reprod Date: 2004-11-04 Impact factor: 6.918

6. Insulin and fatty acids regulate the expression of the fat droplet-associated protein adipophilin in primary human trophoblasts.

Authors: Uriel Elchalal; W Timothy Schaiff; Steven D Smith; Eli Rimon; Ibrahim Bildirici; D Michael Nelson; Yoel Sadovsky
Journal: Am J Obstet Gynecol Date: 2005-11 Impact factor: 8.661

7. Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency.

Authors: Anne Liese Magnusson-Olsson; Susanne Lager; Bo Jacobsson; Thomas Jansson; Theresa L Powell
Journal: Am J Physiol Endocrinol Metab Date: 2007-02-13 Impact factor: 4.310

8. Fatty acids alter glycerolipid metabolism and induce lipid droplet formation, syncytialisation and cytokine production in human trophoblasts with minimal glucose effect or interaction.

Authors: A N Pathmaperuma; P Maña; S N Cheung; K Kugathas; A Josiah; M E Koina; A Broomfield; V Delghingaro-Augusto; D A Ellwood; J E Dahlstrom; C J Nolan
Journal: Placenta Date: 2010-01-20 Impact factor: 3.481

9. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta.

Authors: J C Challier; S Basu; T Bintein; J Minium; K Hotmire; P M Catalano; S Hauguel-de Mouzon
Journal: Placenta Date: 2008-02-11 Impact factor: 3.481

10. Placental structure and inflammation in pregnancies associated with obesity.

Authors: K A Roberts; S C Riley; R M Reynolds; S Barr; M Evans; A Statham; K Hor; H N Jabbour; J E Norman; F C Denison
Journal: Placenta Date: 2011-01-12 Impact factor: 3.481

6 in total

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Authors: Susanne Lager; Thomas Jansson; Theresa L Powell
Journal: Am J Physiol Cell Physiol Date: 2014-10-15 Impact factor: 4.249

2. Functional expression of the free fatty acids receptor-1 and -4 (FFA1/GPR40 and FFA4/GPR120) in bovine endometrial cells.

Authors: Pamela Valenzuela; Stefanie Teuber; Carolina Manosalva; Pablo Alarcón; Carlos D Figueroa; Marcelo Ratto; Rafael A Burgos; Maria A Hidalgo
Journal: Vet Res Commun Date: 2019-06-11 Impact factor: 2.459

3. Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties.

Authors: Véronique Ferchaud-Roucher; Kelsey Barner; Thomas Jansson; Theresa L Powell
Journal: FASEB J Date: 2019-02-27 Impact factor: 5.834