| Literature DB >> 24844196 |
Shikha S Chauhan1, Anup K Singh2, Sanjeev Meena2, Minaxi Lohani3, Akhilesh Singh2, Rakesh K Arya2, Srikanth H Cheruvu4, Jayanta Sarkar2, Jiaur R Gayen4, Dipak Datta2, Prem M S Chauhan5.
Abstract
A series of novel β-carboline based chalcones was synthesized and evaluated for their cytotoxic activity against a panel of human cancer cell lines. Among them we found that two of the compounds 7c and 7d, showed marked anti-proliferative activity in a panel of solid tumor cell lines with highest effect in breast cancer. The compounds 7c and 7d showed an IC50 of 2.25 and 3.29 μM, respectively against human breast cancer MCF-7 cell line. Further, the compound 7c markedly induced DNA fragmentation and apoptosis in breast cancer cells.Entities:
Keywords: Anticancer; Chalcone; Cytotoxic; β-Carboline
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Year: 2014 PMID： 24844196 DOI： 10.1016/j.bmcl.2014.04.109
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823