J K Afolabi1, A Fadeyi2, O O Desalu3, I A Durotoye4, A E Fawibe3, M A N Adeboye1, H O Olawumi4, A S Babatunde4, S K Ernest1, S A Aderibigbe5, R Saadu6, A K Salami3, A P Aboyeji6. 1. 1 Peadiatric Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria. 2. 2 Medical Microbiology & Parasitology Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria. 3. 3 Medicine Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria. 4. 4 Haematology Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria. 5. 5 Community Health Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria. 6. 6 Obstetrics & Gynaecology Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Abstract
BACKGROUND: For the establishment and monitoring of the immune status, CD4 count is critical. OBJECTIVES: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. METHODS: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. RESULTS: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm3 (19%-48%) and for children was 582 to 3652 cells/mm3 (17%-50%). CD4 count and percentage of CD4 were significantly ( P = .001) higher in females than in males, and the CD4 count declined significantly with increasing age ( r = -.174, P ≤ .0001). The percentage of CD4 count shows less variation with age ( r = -.051, P = .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 ± 260) than that of the national reference values of 847.0 ± 307.0 cells/mm3 ( P = .001). CONCLUSION: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.
BACKGROUND: For the establishment and monitoring of the immune status, CD4 count is critical. OBJECTIVES: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. METHODS: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. RESULTS: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm3 (19%-48%) and for children was 582 to 3652 cells/mm3 (17%-50%). CD4 count and percentage of CD4 were significantly ( P = .001) higher in females than in males, and the CD4 count declined significantly with increasing age ( r = -.174, P ≤ .0001). The percentage of CD4 count shows less variation with age ( r = -.051, P = .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 ± 260) than that of the national reference values of 847.0 ± 307.0 cells/mm3 ( P = .001). CONCLUSION: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.
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