Literature DB >> 24842611

MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN.

Ting-Song Yang1, Xiao-Hu Yang2, Xi Chen3, Xu-Dong Wang4, Jie Hua5, Dong-Lei Zhou6, Bo Zhou7, Zhen-Shun Song8.   

Abstract

It is well established that the interaction between cancer cells and microenvironment has a critical role in tumor development, but the roles of miRNAs in this interaction are rarely known. Here, we have shown that miR-106b is up-regulated in cancer associated fibroblasts compared with normal fibroblasts established from patients with gastric cancer, the expression level of miR-106b is associated with poor prognosis of patients, and CAFs with down-regulated miR-106b could significantly inhibit gastric cancer cell migration and invasion by targeting PTEN. Taken together, these data suggest that miR-106b might be a novel candidate target for the treatment of gastric cancer.
Copyright © 2014. Published by Elsevier B.V.

Entities:  

Keywords:  Cancer associated fibroblasts; Gastric cancer; Protein tyrosine phosphatase and tensin homologue; microRNA

Mesh：

Substances：

Year:  2014        PMID： 24842611     DOI： 10.1016/j.febslet.2014.04.050

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  53 in total

1.  Repetitive magnetic stimulation promotes neural stem cells proliferation by upregulating MiR-106b in vitro.

Authors:  Hua Liu; Xiao-Hua Han; Hong Chen; Cai-Xia Zheng; Yi Yang; Xiao-Lin Huang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2015-10-22

Review 2.  Tracking miRNAs' footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy.

Authors:  Nazila Nouraee; Seyed Javad Mowla; George A Calin
Journal:  Genes Chromosomes Cancer       Date:  2015-03-31       Impact factor: 5.006

3.  Downregulation of serum miR-17 and miR-106b levels in gastric cancer and benign gastric diseases.

Authors:  Qinghai Zeng; Cuihong Jin; Wenhang Chen; Fang Xia; Qi Wang; Fan Fan; Juan Du; Yihang Guo; Changwei Lin; Kaiyan Yang; Jingjing Li; Xiaowei Peng; Xiaorong Li; Ke Cao
Journal:  Chin J Cancer Res       Date:  2014-12       Impact factor: 5.087

Review 4.  MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer.

Authors:  C Jiang; X Chen; M Alattar; J Wei; H Liu
Journal:  Cancer Gene Ther       Date:  2015-05-22       Impact factor: 5.987

Review 5.  Epigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesis.

Authors:  Juliana Carvalho Santos; Marcelo Lima Ribeiro
Journal:  World J Gastroenterol       Date:  2015-08-14       Impact factor: 5.742

Review 6.  Epigenetic control of the tumor microenvironment.

Authors:  David L Marks; Rachel Lo Olson; Martin E Fernandez-Zapico
Journal:  Epigenomics       Date:  2016-10-04       Impact factor: 4.778

Review 7.  Circulating microRNAs and long non-coding RNAs in gastric cancer diagnosis: An update and review.

Authors:  Ya-Kai Huang; Jian-Chun Yu
Journal:  World J Gastroenterol       Date:  2015-09-14       Impact factor: 5.742

8.  Cancer-associated fibroblasts regulate the biological behavior of cancer cells and stroma in gastric cancer.

Authors:  Qian Zhang; Chunwei Peng
Journal:  Oncol Lett       Date:  2017-11-09       Impact factor: 2.967

9.  MicroRNA-106b promotes pituitary tumor cell proliferation and invasion through PI3K/AKT signaling pathway by targeting PTEN.

Authors:  Kai Zhou; Tingrong Zhang; YanDong Fan; Guojia Du; Pengfei Wu; Dangmurenjiafu Geng
Journal:  Tumour Biol       Date:  2016-07-27

10.  MiR-106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma.

Authors:  Fang Dai; Tao Liu; Shutao Zheng; Qing Liu; Chenchen Yang; Jian Zhou; Yumei Chen; Ilyar Sheyhidin; Xiaomei Lu
Journal:  Tumour Biol       Date:  2016-09-12
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