Literature DB >> 24842610

Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.

Sam X Cheng1, Yaíma L Lightfoot2, Tao Yang2, Mojgan Zadeh2, Lieqi Tang1, Bikash Sahay2, Gary P Wang3, Jennifer L Owen4, Mansour Mohamadzadeh5.   

Abstract

The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr(-/-) mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases.
Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Calcium-sensing receptor; Colitis; Epithelial cell; Gut microbiota; Inflammation; Intestinal barrier function

Mesh：

Substances：

Year:  2014        PMID： 24842610      PMCID： PMC4234694          DOI： 10.1016/j.febslet.2014.05.007

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  65 in total

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