PRIMARY OBJECTIVE: To evaluate excitability and inhibition of the motor cortex acutely and longitudinally following mild traumatic brain injury (mTBI). RESEARCH DESIGN: A longitudinal paired case-control design was used to examine cortical excitability and inhibition in 15 adults who had sustained an mTBI (mean age = 20.8 ± 1.2 years) and 15 matched control participants (mean age = 21.1 ± 1.3 years). METHODS AND PROCEDURES: Participants visited the lab within 72 hours of injury and again at 1, 2, 4 and 8 weeks post-injury. During each visit, transcranial magnetic stimulation was used to examine resting motor threshold (RMT), motor evoked potential peak-to-peak amplitude (MEPamp) and cortical silent period (CSP) duration of the first dorsal interosseous muscle. MAIN OUTCOMES AND RESULTS: There were no differences between groups in RMT (p = 0.10) or MEPamp (p = 0.22) at 72 hours post-injury or across the 2-month testing period (p ≥ 0.68), indicating similar cortical excitability. However, the CSP duration was higher in individuals with mTBI, indicating greater intra-cortical inhibition compared with the control group at 72 hours post-injury (p = 0.03) and throughout the 2 months of recovery (p = 0.009). CONCLUSIONS: mTBI appeared to have little effect on cortical excitability, but an acute and long-lasting effect on intra-cortical inhibition.
PRIMARY OBJECTIVE: To evaluate excitability and inhibition of the motor cortex acutely and longitudinally following mild traumatic brain injury (mTBI). RESEARCH DESIGN: A longitudinal paired case-control design was used to examine cortical excitability and inhibition in 15 adults who had sustained an mTBI (mean age = 20.8 ± 1.2 years) and 15 matched control participants (mean age = 21.1 ± 1.3 years). METHODS AND PROCEDURES: Participants visited the lab within 72 hours of injury and again at 1, 2, 4 and 8 weeks post-injury. During each visit, transcranial magnetic stimulation was used to examine resting motor threshold (RMT), motor evoked potential peak-to-peak amplitude (MEPamp) and cortical silent period (CSP) duration of the first dorsal interosseous muscle. MAIN OUTCOMES AND RESULTS: There were no differences between groups in RMT (p = 0.10) or MEPamp (p = 0.22) at 72 hours post-injury or across the 2-month testing period (p ≥ 0.68), indicating similar cortical excitability. However, the CSP duration was higher in individuals with mTBI, indicating greater intra-cortical inhibition compared with the control group at 72 hours post-injury (p = 0.03) and throughout the 2 months of recovery (p = 0.009). CONCLUSIONS: mTBI appeared to have little effect on cortical excitability, but an acute and long-lasting effect on intra-cortical inhibition.
Authors: Thomas G Di Virgilio; Angus Hunter; Lindsay Wilson; William Stewart; Stuart Goodall; Glyn Howatson; David I Donaldson; Magdalena Ietswaart Journal: EBioMedicine Date: 2016-10-23 Impact factor: 8.143
Authors: Thomas G Di Virgilio; Magdalena Ietswaart; Lindsay Wilson; David I Donaldson; Angus M Hunter Journal: Front Hum Neurosci Date: 2019-09-10 Impact factor: 3.169
Authors: Cintya Yukie Hayashi; Iuri Santana Neville; Priscila Aparecida Rodrigues; Ricardo Galhardoni; André Russowsky Brunoni; Ana Luiza Zaninotto; Vinicius Monteiro de Paula Guirado; Ana Sofia Cueva; Daniel Ciampi de Andrade; Manoel Jacobsen Teixeira; Wellingson Silva Paiva Journal: Front Neurol Date: 2018-03-28 Impact factor: 4.003