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Literature DB >> 24840983

Immune diseases caused by mutations in kinases and components of the ubiquitin system.

Abstract

The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.

Entities: Chemical

Mesh：

Substances：

Year: 2014 PMID： 24840983 PMCID： PMC5793992 DOI： 10.1038/ni.2892

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

128 in total

1. Regulation of T cell development by the deubiquitinating enzyme CYLD.

Authors: William W Reiley; Minying Zhang; Wei Jin; Mandy Losiewicz; Keri B Donohue; Christopher C Norbury; Shao-Cong Sun
Journal: Nat Immunol Date: 2006-02-26 Impact factor: 25.606

2. Negative regulation of toll-like receptor-mediated signaling by Tollip.

Authors: Guolong Zhang; Sankar Ghosh
Journal: J Biol Chem Date: 2001-12-18 Impact factor: 5.157

3. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.

Authors: Heon Park; Zhaoxia Li; Xuexian O Yang; Seon Hee Chang; Roza Nurieva; Yi-Hong Wang; Ying Wang; Leroy Hood; Zhou Zhu; Qiang Tian; Chen Dong
Journal: Nat Immunol Date: 2005-10-02 Impact factor: 25.606

Review 4. Human tyk2 kinase deficiency: another primary immunodeficiency syndrome.

Authors: Wendy T Watford; John J O'Shea
Journal: Immunity Date: 2006-11 Impact factor: 31.745

Review 5. The genetics and immunopathogenesis of inflammatory bowel disease.

Authors: Judy H Cho
Journal: Nat Rev Immunol Date: 2008-06 Impact factor: 53.106

6. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1.

Authors: J H Cho; D L Nicolae; L H Gold; C T Fields; M C LaBuda; P M Rohal; M R Pickles; L Qin; Y Fu; J S Mann; B S Kirschner; E W Jabs; J Weber; S B Hanauer; T M Bayless; S R Brant
Journal: Proc Natl Acad Sci U S A Date: 1998-06-23 Impact factor: 11.205

7. A LAT mutation that inhibits T cell development yet induces lymphoproliferation.

Authors: Connie L Sommers; Cheung-Seog Park; Jan Lee; Chiguang Feng; Claudette L Fuller; Alexander Grinberg; Jay A Hildebrand; Emanuela Lacaná; Rashmi K Menon; Elizabeth W Shores; Lawrence E Samelson; Paul E Love
Journal: Science Date: 2002-06-14 Impact factor: 47.728

8. Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

Authors: Olivier Boulard; Stefanie Kirchberger; Daniel J Royston; Kevin J Maloy; Fiona M Powrie
Journal: J Exp Med Date: 2012-06-25 Impact factor: 14.307

9. PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages.

Authors: Louis de Léséleuc; Marianna Orlova; Aurelie Cobat; Manon Girard; Nguyen Thu Huong; Nguyen Ngoc Ba; Nguyen Van Thuc; Richard Truman; John S Spencer; Linda Adams; Vu Hong Thai; Alexandre Alcais; Erwin Schurr
Journal: PLoS Negl Trop Dis Date: 2013-01-17

10. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis.

Authors: Heather R Conti; Fang Shen; Namrata Nayyar; Eileen Stocum; Jianing N Sun; Matthew J Lindemann; Allen W Ho; Justine Hoda Hai; Jeffrey J Yu; Ji Won Jung; Scott G Filler; Patricia Masso-Welch; Mira Edgerton; Sarah L Gaffen
Journal: J Exp Med Date: 2009-02-09 Impact factor: 14.307

19 in total

Review 1. Cellular and molecular regulation of innate inflammatory responses.

Authors: Juan Liu; Xuetao Cao
Journal: Cell Mol Immunol Date: 2016-10-31 Impact factor: 11.530

Review 2. Assembly and regulation of ASC specks.

Authors: Florian Hoss; Juan F Rodriguez-Alcazar; Eicke Latz
Journal: Cell Mol Life Sci Date: 2016-10-19 Impact factor: 9.261

Review 3. Geoepidemiology and Immunologic Features of Autoinflammatory Diseases: a Comprehensive Review.

Authors: Yvan Jamilloux; Alexandre Belot; Flora Magnotti; Sarah Benezech; Mathieu Gerfaud-Valentin; Emilie Bourdonnay; Thierry Walzer; Pascal Sève; Thomas Henry
Journal: Clin Rev Allergy Immunol Date: 2018-06 Impact factor: 8.667

Review 4. Lessons from characterization and treatment of the autoinflammatory syndromes.

Authors: Ivona Aksentijevich; Michael F McDermott
Journal: Curr Opin Rheumatol Date: 2017-03 Impact factor: 5.006

5. MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.

Authors: Ekaterina Kotelnikova; Narsis A Kiani; Dimitris Messinis; Inna Pertsovskaya; Vicky Pliaka; Marti Bernardo-Faura; Melanie Rinas; Gemma Vila; Irati Zubizarreta; Irene Pulido-Valdeolivas; Theodore Sakellaropoulos; Wolfgang Faigle; Gilad Silberberg; Mar Masso; Pernilla Stridh; Janina Behrens; Tomas Olsson; Roland Martin; Friedemann Paul; Leonidas G Alexopoulos; Julio Saez-Rodriguez; Jesper Tegner; Pablo Villoslada
Journal: Proc Natl Acad Sci U S A Date: 2019-04-19 Impact factor: 11.205

Review 6. Small-molecule control of cytokine function: new opportunities for treating immune disorders.

Authors: Thomas B Sundberg; Ramnik J Xavier; Stuart L Schreiber; Alykhan F Shamji
Journal: Curr Opin Chem Biol Date: 2014-09-15 Impact factor: 8.822

7. High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry-based deubiquitylating enzyme assay for drug discovery.

Authors: Virginia De Cesare; Jennifer Moran; Ryan Traynor; Axel Knebel; Maria Stella Ritorto; Matthias Trost; Hilary McLauchlan; C James Hastie; Paul Davies
Journal: Nat Protoc Date: 2020-11-02 Impact factor: 13.491