| Literature DB >> 2484089 |
Abstract
Microvascular permeability changes (using FITC-dextran 150 clearance as an index) produced by ischemia-reperfusion (I-R) were investigated in the rat cremaster muscle. I-R produced significant sustained increases in microvascular permeability to macromolecules. Pretreatment with dexamethasone and verapamil reduced this I-R effect. Leukopenia also afforded protection to the microcirculation. It was concluded that changes occurring during ischemia are major causative components of the ischemia-reperfusion damage.Entities:
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Year: 1989 PMID： 2484089
Source DB: PubMed Journal: Microcirc Endothelium Lymphatics ISSN： 0740-9451