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Literature DB >> 24840801

Neurobiology of food intake in health and disease.

Gregory J Morton¹, Thomas H Meek¹, Michael W Schwartz¹.

Abstract

Under normal conditions, food intake and energy expenditure are balanced by a homeostatic system that maintains stability of body fat content over time. However, this homeostatic system can be overridden by the activation of 'emergency response circuits' that mediate feeding responses to emergent or stressful stimuli. Inhibition of these circuits is therefore permissive for normal energy homeostasis to occur, and their chronic activation can cause profound, even life-threatening, changes in body fat mass. This Review highlights how the interplay between homeostatic and emergency feeding circuits influences the biologically defended level of body weight under physiological and pathophysiological conditions.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2014 PMID： 24840801 PMCID： PMC4076116 DOI： 10.1038/nrn3745

Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870

169 in total

1. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons.

Authors: T M Hahn; J F Breininger; D G Baskin; M W Schwartz
Journal: Nat Neurosci Date: 1998-08 Impact factor: 24.884

2. A frameshift mutation in human MC4R is associated with a dominant form of obesity.

Authors: C Vaisse; K Clement; B Guy-Grand; P Froguel
Journal: Nat Genet Date: 1998-10 Impact factor: 38.330

3. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.

Authors: M D Barrachina; V Martínez; L Wang; J Y Wei; Y Taché
Journal: Proc Natl Acad Sci U S A Date: 1997-09-16 Impact factor: 11.205

4. Effect of alloxan on feed consumption and on replacement therapy with graded levels of insulin in rats.

Authors: P Kumaresan; C W Turner
Journal: Proc Soc Exp Biol Med Date: 1966-06

Review 5. Optogenetic pharmacology for control of native neuronal signaling proteins.

Authors: Richard H Kramer; Alexandre Mourot; Hillel Adesnik
Journal: Nat Neurosci Date: 2013-06-25 Impact factor: 24.884

6. Central leptin modulates behavioral and neural responsivity to CCK.

Authors: M Emond; G J Schwartz; E E Ladenheim; T H Moran
Journal: Am J Physiol Date: 1999-05

7. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

Authors: Nina Balthasar; Roberto Coppari; Julie McMinn; Shun M Liu; Charlotte E Lee; Vinsee Tang; Christopher D Kenny; Robert A McGovern; Streamson C Chua; Joel K Elmquist; Bradford B Lowell
Journal: Neuron Date: 2004-06-24 Impact factor: 17.173

Review 8. Glucose-sensing neurons: are they physiologically relevant?

Authors: Vanessa H Routh
Journal: Physiol Behav Date: 2002-07

9. Corrective responses in human food intake identified from an analysis of 7-d food-intake records.

Authors: George A Bray; Jean-Pierre Flatt; Julia Volaufova; James P Delany; Catherine M Champagne
Journal: Am J Clin Nutr Date: 2008-12 Impact factor: 7.045

10. Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation.

Authors: Qi Wu; Maureen P Boyle; Richard D Palmiter
Journal: Cell Date: 2009-06-26 Impact factor: 41.582

194 in total

1. Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

Authors: Jer-Yuan Hsu; Suzanne Crawley; Michael Chen; Dina A Ayupova; Darrin A Lindhout; Jared Higbee; Alan Kutach; William Joo; Zhengyu Gao; Diana Fu; Carmen To; Kalyani Mondal; Betty Li; Avantika Kekatpure; Marilyn Wang; Teresa Laird; Geoffrey Horner; Jackie Chan; Michele McEntee; Manuel Lopez; Damodharan Lakshminarasimhan; Andre White; Sheng-Ping Wang; Jun Yao; Junming Yie; Hugo Matern; Mark Solloway; Raj Haldankar; Thomas Parsons; Jie Tang; Wenyan D Shen; Yu Alice Chen; Hui Tian; Bernard B Allan
Journal: Nature Date: 2017-09-27 Impact factor: 49.962

Neurobiology of food intake in health and disease.

1. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons.

2. A frameshift mutation in human MC4R is associated with a dominant form of obesity.

3. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.

4. Effect of alloxan on feed consumption and on replacement therapy with graded levels of insulin in rats.

Review 5. Optogenetic pharmacology for control of native neuronal signaling proteins.

6. Central leptin modulates behavioral and neural responsivity to CCK.

7. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

Review 8. Glucose-sensing neurons: are they physiologically relevant?

9. Corrective responses in human food intake identified from an analysis of 7-d food-intake records.

10. Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation.

1. Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

2. A high-throughput assay for quantifying appetite and digestive dynamics.

Review 3. Gastric electrical stimulation for obesity.

Review 4. Obesity and the neurocognitive basis of food reward and the control of intake.

Review 5. Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms.

Review 6. Using the cerebrospinal fluid to understand ingestive behavior.

7. Behavioral Characteristics of Adult Zebrafish (Danio rerio) after MS222 Anesthesia for Fin Excision.

Review 8. Obesity and Brain Positron Emission Tomography.

9. High on food: the interaction between the neural circuits for feeding and for reward.

10. Genetic mapping of etiologic brain cell types for obesity.