Silver-mediated radical cyclization: construction of Δ(2)-isoxazolines from α-halo ketoximes and 1,3-dicarbonyl compounds.

A novel route to Δ(2)-isoxazolines is presented via silver-mediated radical cyclization of α-halo ketoximes with 1,3-dicarbonyl compounds. This method is performed using a radical strategy, and represents a new example of silver-initiated generation of oxime radicals for the formation of the C(sp(3))-O bonds.