Literature DB >> 24840565

A lack of correlation between the incidence of lyme disease and deaths due to Alzheimer's disease.

Danton H O'Day1, Andrew Catalano2.   

Abstract

Reports that Lyme disease (LD) causes Alzheimer's disease (AD) have appeared in academic journals and online. If the biological agent Borrelia burgdorferi that causes LD also causes AD, then areas with the highest levels of LD should have significantly higher numbers of deaths due to AD compared to low LD areas. Here we show there is no statistically significant correlation between the incidence of LD and deaths due to AD in the US. Furthermore, the 13 states with the highest deaths due to AD were statistically different (p < 0.0001) from those with high LD incidence.

Entities:  

Keywords:  Alzheimer's disease; Borrelia burgdorferi; disease incidence; lyme disease

Mesh:

Year:  2014        PMID: 24840565     DOI: 10.3233/JAD-140552

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN: 1387-2877            Impact factor:   4.472


  5 in total

1.  The Role of Chronic Infection in Alzheimer's Disease: Instigators, Co-conspirators, or Bystanders?

Authors:  Lauren Butler; Keenan A Walker
Journal:  Curr Clin Microbiol Rep       Date:  2021-04-24

2.  Lack of Convincing Evidence That Borrelia burgdorferi Infection Causes Either Alzheimer Disease or Lewy Body Dementia.

Authors:  Gary P Wormser; Adriana Marques; Charles S Pavia; Ira Schwartz; Henry M Feder; Andrew R Pachner
Journal:  Clin Infect Dis       Date:  2022-08-25       Impact factor: 20.999

3.  No Geographic Correlation between Lyme Disease and Death Due to 4 Neurodegenerative Disorders, United States, 2001-2010.

Authors:  Joseph D Forrester; Kiersten J Kugeler; Anna E Perea; Daniel M Pastula; Paul S Mead
Journal:  Emerg Infect Dis       Date:  2015-11       Impact factor: 6.883

4.  Borrelia burgdorferi Co-Localizing with Amyloid Markers in Alzheimer's Disease Brain Tissues.

Authors:  Alireza G Senejani; Jasmin Maghsoudlou; Dina El-Zohiry; Gauri Gaur; Keith Wawrzeniak; Cristina Caravaglia; Vishwa A Khatri; Alan MacDonald; Eva Sapi
Journal:  J Alzheimers Dis       Date:  2022       Impact factor: 4.472

Review 5.  Role of Microbes in the Development of Alzheimer's Disease: State of the Art - An International Symposium Presented at the 2017 IAGG Congress in San Francisco.

Authors:  Tamàs Fülöp; Ruth F Itzhaki; Brian J Balin; Judith Miklossy; Annelise E Barron
Journal:  Front Genet       Date:  2018-09-10       Impact factor: 4.599

  5 in total

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