Double C-F bond activation through β-fluorine elimination: nickel-mediated [3+2] cycloaddition of 2-trifluoromethyl-1-alkenes with alkynes.

The nickel-mediated [3+2] cycloaddition of 2-trifluoromethyl-1-alkenes with alkynes afforded fluorine-containing multi-substituted cyclopentadienes in a regioselective manner. This reaction involves the consecutive two C-F bond cleavage of a trifluoromethyl or a pentafluoroethyl group through β-fluorine elimination.