| Literature DB >> 24838883 |
Choon Kit Wong1, Mui Hua Tan, Bahareh Haji Rasouliha, In Young Hwang, Hua Ling, Chueh Loo Poh, Matthew Wook Chang.
Abstract
The rapid emergence of multidrug-resistant pathogens has invoked concerns of our current limitations in controlling the spread of infectious disease. To resolve this, we have applied synthetic biology principles to engineer human commensal microbe that can specifically sense and kill an antibiotic-resistant strain of P. aeruginosa. In this chapter, we describe the methods used to assemble, characterize, and evaluate the effectiveness of our engineered microbe in multicellular systems.Entities:
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Year: 2014 PMID： 24838883 DOI： 10.1007/978-1-4939-0554-6_9
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745