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Literature DB >> 2483716

T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506.

Abstract

Nanomolar concentrations of the novel immunosuppressive drug FK-506 inhibit the proliferation of human T lymphocytes in vitro induced by mitogenic lectins or by monoclonal antibodies directed against the CD3 or CD2 surface antigens. However, the alternative pathway of T lymphocyte proliferation induced by monoclonal antibodies specific for CD28 together with phorbol esters is unaffected by FK-506.

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Year: 1989 PMID： 2483716 DOI： 10.1016/0165-2478(89)90129-6

Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685

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Cited

6 in total

1. Mechanism responsible for T-cell antigen receptor- and CD28- or interleukin 1 (IL-1) receptor-initiated regulation of IL-2 gene expression by NF-kappaB.

Authors: K Kalli; C Huntoon; M Bell; D J McKean
Journal: Mol Cell Biol Date: 1998-06 Impact factor: 4.272

2. The immunosuppressant rapamycin represses human immunodeficiency virus type 1 replication.

Authors: Jocelyn Roy; Jean-Sébastien Paquette; Jean-François Fortin; Michel J Tremblay
Journal: Antimicrob Agents Chemother Date: 2002-11 Impact factor: 5.191

3. The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1.

Authors: S S Banerji; J N Parsons; M J Tocci
Journal: Mol Cell Biol Date: 1991-08 Impact factor: 4.272

T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506.

1. Mechanism responsible for T-cell antigen receptor- and CD28- or interleukin 1 (IL-1) receptor-initiated regulation of IL-2 gene expression by NF-kappaB.

2. The immunosuppressant rapamycin represses human immunodeficiency virus type 1 replication.

3. The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1.

4. Inhibition of T and B lymphocyte proliferation by rapamycin.

Review 5. Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation.

6. Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level.