| Literature DB >> 24837158 |
Shinya Nagashima1, Yuji Matsushima2, Hisao Hamaguchi2, Hiroshi Nagata2, Toru Kontani2, Ayako Moritomo2, Tadatsura Koshika2, Makoto Takeuchi2.
Abstract
Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.Entities:
Keywords: ASP9133; COPD; In vivo selectivity; Long acting muscarinic receptor antagonist
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Year: 2014 PMID： 24837158 DOI： 10.1016/j.bmc.2014.04.031
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641