John B Chambers 1 , Paul T Seed 2 , Leone Ridsdale 3 Show Affiliations »
Abstract
INTRODUCTION: Anecdotal reports suggest that clopidogrel may prevent migraine attacks. We undertook a pilot randomised trial. METHOD: We randomised consecutive migraineurs with four to 15 headache days per 28-day month to receive clopidogrel 75 mg or placebo daily for three months. Headache was primarily assessed with a headache diary. RESULTS: There were no statistically significant treatment effects. The number of headache days fell by 1.9 on clopidogrel and 1.6 on placebo (adjusted difference 0.02, CI -2.07 to 2.12). Headache severity rose by 0.14 points (out of 10) on clopidogrel, and fell by 0.63 on placebo; treatment effect 0.7 points (CI -0.11 to 1.57). The main treatment effect did not depend on the presence or absence of migraine with aura at baseline, a patent foramen ovale (PFO) or atrial septal aneurysm. DISCUSSION: The evidence is inconclusive, but a multicentre trial would be feasible recruiting from primary care. © International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
INTRODUCTION: Anecdotal reports suggest that clopidogrel may prevent migraine attacks. We undertook a pilot randomised trial. METHOD: We randomised consecutive migraineurs with four to 15 headache days per 28-day month to receive clopidogrel 75 mg or placebo daily for three months. Headache was primarily assessed with a headache diary. RESULTS: There were no statistically significant treatment effects. The number of headache days fell by 1.9 on clopidogrel and 1.6 on placebo (adjusted difference 0.02, CI -2.07 to 2.12). Headache severity rose by 0.14 points (out of 10) on clopidogrel, and fell by 0.63 on placebo; treatment effect 0.7 points (CI -0.11 to 1.57). The main treatment effect did not depend on the presence or absence of migraine with aura at baseline, a patent foramen ovale (PFO) or atrial septal aneurysm. DISCUSSION: The evidence is inconclusive, but a multicentre trial would be feasible recruiting from primary care. © International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Entities: Chemical
Keywords:
Migraine; clopidogrel
Mesh： See more »
Substances： See more »
Year: 2014
PMID： 24836213 DOI： 10.1177/0333102414531156
Source DB: PubMed Journal: Cephalalgia ISSN： 0333-1024 Impact factor: 6.292