Lise M Lindahl1, Morten Fenger-Grøn2, Lars Iversen3. 1. Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: lise.lindahl@ki.au.dk. 2. Department of Clinical Epidemiology, Aarhus University Hospital and Research Unit for General Practice, Aarhus University, Aarhus, Denmark. 3. Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
Abstract
BACKGROUND: Data on subsequent cancers, prognostic factors for mortality, and causes of death are limited in mycosis fungoides (MF) and parapsoriasis. OBJECTIVES: To assess subsequent cancers, mortality, and causes of death in MF and parapsoriasis. METHODS: Using the Danish nationwide population-based registries, we identified 368 MF patients and 582 parapsoriasis patients and compared them with the general Danish population for subsequent cancers, mortality, and causes of death. RESULTS: Subsequent cancers were significantly increased in parapsoriasis patients (standardized incidence ratio [SIR], 2.0 [95% confidence interval {CI}, 1.6-2.5]), and a trend was observed in MF (SIR, 1.2 [95% CI, 0.9-1.5]). Mortality was significantly increased in MF (SIR, 2.0 [95% CI, 1.8-2.3]) and parapsoriasis (SIR, 1.3 [95% CI, 1.1-1.5]). Excess mortality from MF was highest during the first 5 years of follow-up, and causes of increased death included both malignant and nonmalignant diseases. LIMITATIONS: We have no information regarding clinical stage, treatments, and patient lifestyles. CONCLUSION: Patients with parapsoriasis had a significantly increased risk of subsequent cancers and increased mortality. In addition, the highest excess mortality in the MF group was observed during the first 5 years of follow-up, which suggests that MF exists in both an aggressive and a more indolent form.
BACKGROUND: Data on subsequent cancers, prognostic factors for mortality, and causes of death are limited in mycosis fungoides (MF) and parapsoriasis. OBJECTIVES: To assess subsequent cancers, mortality, and causes of death in MF and parapsoriasis. METHODS: Using the Danish nationwide population-based registries, we identified 368 MF patients and 582 parapsoriasispatients and compared them with the general Danish population for subsequent cancers, mortality, and causes of death. RESULTS: Subsequent cancers were significantly increased in parapsoriasispatients (standardized incidence ratio [SIR], 2.0 [95% confidence interval {CI}, 1.6-2.5]), and a trend was observed in MF (SIR, 1.2 [95% CI, 0.9-1.5]). Mortality was significantly increased in MF (SIR, 2.0 [95% CI, 1.8-2.3]) and parapsoriasis (SIR, 1.3 [95% CI, 1.1-1.5]). Excess mortality from MF was highest during the first 5 years of follow-up, and causes of increased death included both malignant and nonmalignant diseases. LIMITATIONS: We have no information regarding clinical stage, treatments, and patient lifestyles. CONCLUSION:Patients with parapsoriasis had a significantly increased risk of subsequent cancers and increased mortality. In addition, the highest excess mortality in the MF group was observed during the first 5 years of follow-up, which suggests that MF exists in both an aggressive and a more indolent form.
Authors: Amrita Goyal; Daniel O'Leary; Kavita Goyal; Nathan Rubin; Kimberly Bohjanen; Maria Hordinsky; Steven T Chen; Georgios Pongas; Lyn M Duncan; Aleksandr Lazaryan Journal: J Am Acad Dermatol Date: 2019-07-30 Impact factor: 11.527
Authors: N Odum; L M Lindahl; M Wod; T Krejsgaard; A Skytthe; A Woetmann; L Iversen; K Christensen Journal: Blood Cancer J Date: 2017-01-20 Impact factor: 11.037
Authors: Subuhi Kaul; Micah Belzberg; John-Douglas Matthew Hughes; Varun Mahadevan; Raveena Khanna; Pegah R Bakhshi; Michael S Hong; Kyle A Williams; Annie L Grossberg; Shawn G Kwatra; Ronald J Sweren Journal: Medicines (Basel) Date: 2019-12-26