Literature DB >> 24835789

Synthesis and biological activity of new arenediyne-linked isoxazolidines.

Roberto Romeo1, Michele Navarra2, Salvatore V Giofrè3, Caterina Carnovale2, Santa Cirmi2, Giuseppe Lanza4, Maria A Chiacchio4.   

Abstract

Arenediyne-isoxazolidine conjugates have been synthesized as a new scaffold for the development of bioactive mimics. Some of the synthesized compounds are endowed with antiproliferative activity against three human cancer cell lines. Their thermal reactivity suggests that the biological activity probably could not be linked to the Bergman cyclization.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  1,3-Dipolar cycloaddition; Antitumor agents; Arenediyne–isoxazolidine conjugates; SH-SY5Y, HT-29, HepG2 cell lines; Sonogashira reaction

Mesh：

Substances：

Year:  2014        PMID： 24835789     DOI： 10.1016/j.bmc.2014.04.047

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation.

Authors:  Roberto Romeo; Caterina Carnovale; Salvatore V Giofrè; Maria A Chiacchio; Adriana Garozzo; Emanuele Amata; Giovanni Romeo; Ugo Chiacchio
Journal:  Beilstein J Org Chem       Date:  2015-03-09       Impact factor: 2.883

2.  Synthesis of spiro[isoindole-1,5'-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction.

Authors:  Salvatore V Giofrè; Santa Cirmi; Raffaella Mancuso; Francesco Nicolò; Giuseppe Lanza; Laura Legnani; Agata Campisi; Maria A Chiacchio; Michele Navarra; Bartolo Gabriele; Roberto Romeo
Journal:  Beilstein J Org Chem       Date:  2016-12-20       Impact factor: 2.883

3.  Synthesis and biological properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: a new class of C-nucleosides.

Authors:  Salvatore V Giofrè; Roberto Romeo; Caterina Carnovale; Raffaella Mancuso; Santa Cirmi; Michele Navarra; Adriana Garozzo; Maria A Chiacchio
Journal:  Molecules       Date:  2015-03-24       Impact factor: 4.411

4.  Ene Reaction of Nitrosocarbonyl Mesitylene with the Cinnamyl Alcohol: Metabolic Activity and Apoptosis of the Synthetized 6-Chloropurine N,O-Nucleoside Analogues.

Authors:  Misal Giuseppe Memeo; Elena Valletta; Beatrice Macchi; Alessio Porta; Bruna Bovio; Mattia Moiola; Paolo Quadrelli
Journal:  ACS Omega       Date:  2018-07-10
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.