Shiyi Cao1, Shengli Yang2, Chao Wu2, Yunxia Wang1, Jianxin Jiang3, Zuxun Lu4. 1. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. 2. Department of General Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. 3. Department of Hepatobiliary Surgery, Affiliated Hospital of Guiyang Medical College, Guizhou, People's Republic of China. Electronic address: jjx731003@163.com. 4. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Electronic address: zuxunlu@yahoo.com.
Abstract
PURPOSE: To investigate the relationship of protein expression of hypoxia-inducible factor-1 alpha (HIF-1α) with clinicopathological factors and prognosis of hepatocellular carcinoma (HCC). METHODS: PubMed and Embase were searched from their inception through August 2013 for studies that reported the association between protein expression of HIF-1α and HCC. Random effects meta-analyses were used to summarize the odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Eight studies involving 851 patients with HCC were included. Protein expression level of HIF-1α was not found to be related with capsule formation, cirrhosis, tumor size, and tumor differentiation of HCC, except vascular invasion. The positive association between HIF-1α expression and vascular invasion of HCC was statistically significant (OR: 2.04, 95% CI: 1.31-3.18). As a prognostic factor, a high level of HIF-1α expression would be associated with a poor disease-free survival (OR: 2.10, 95% CI: 1.48-2.97). CONCLUSION: Higher level of HIF-1α expression may indicate a bigger possibility of vascular invasion and a poorer prognosis of HCC.
PURPOSE: To investigate the relationship of protein expression of hypoxia-inducible factor-1 alpha (HIF-1α) with clinicopathological factors and prognosis of hepatocellular carcinoma (HCC). METHODS: PubMed and Embase were searched from their inception through August 2013 for studies that reported the association between protein expression of HIF-1α and HCC. Random effects meta-analyses were used to summarize the odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Eight studies involving 851 patients with HCC were included. Protein expression level of HIF-1α was not found to be related with capsule formation, cirrhosis, tumor size, and tumor differentiation of HCC, except vascular invasion. The positive association between HIF-1α expression and vascular invasion of HCC was statistically significant (OR: 2.04, 95% CI: 1.31-3.18). As a prognostic factor, a high level of HIF-1α expression would be associated with a poor disease-free survival (OR: 2.10, 95% CI: 1.48-2.97). CONCLUSION: Higher level of HIF-1α expression may indicate a bigger possibility of vascular invasion and a poorer prognosis of HCC.
Authors: Sheng-Li Yang; Li-Ping Liu; Yun-Fan Sun; Xing-Rong Yang; Jia Fan; Jian-Wei Ren; George G Chen; Paul B S Lai Journal: J Gastroenterol Date: 2015-11-25 Impact factor: 7.527
Authors: Sheng-Li Yang; Li-Ping Liu; Leilei Niu; Yun-Fan Sun; Xing-Rong Yang; Jia Fan; Jian-Wei Ren; George G Chen; Paul B S Lai Journal: Oncotarget Date: 2016-06-07