Literature DB >> 2483550

Effects of tachykinins on mucus secretion in human bronchi in vitro.

D F Rogers1, B Aursudkij, P J Barnes.   

Abstract

We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10(-9)-10(-5) M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor phosphoramidon (10(-5) M) potentiated the effect of SP (10(-7) M). SP is a potent stimulant of secretion in human bronchi and enkephalinase may modulate its effects.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2483550     DOI： 10.1016/0014-2999(89)90322-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  18 in total

1.  Neurogenic inflammation in human airways: is it important?

Authors:  G F Joos; P R Germonpre; R A Pauwels
Journal:  Thorax       Date:  1995-03       Impact factor: 9.139

Review 2.  New therapies for chronic obstructive pulmonary disease.

Authors:  P J Barnes
Journal:  Thorax       Date:  1998-02       Impact factor: 9.139

3.  Recombinant bovine neurokinin-2 receptor stably expressed in Chinese hamster ovary cells couples to multiple signal transduction pathways.

Authors:  H R Eistetter; D J Church; A Mills; P P Godfrey; A M Capponi; R Brewster; M F Schulz; E Kawashima; S J Arkinstall
Journal:  Cell Regul       Date:  1991-10

4.  Capsaicin and sensory neuropeptide stimulation of goblet cell secretion in guinea-pig trachea.

Authors:  H P Kuo; J A Rohde; K Tokuyama; P J Barnes; D F Rogers
Journal:  J Physiol       Date:  1990-12       Impact factor: 5.182

5.  The involvement of sensory neuropeptides in toluene diisocyanate-induced tracheal hyperreactivity in the mouse airways.

Authors:  H Scheerens; T L Buckley; T Muis; H Van Loveren; F P Nijkamp
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

6.  Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.

Authors:  Y Hirayama; Y H Lei; P J Barnes; D F Rogers
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

7.  Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats.

Authors:  N E Bowring; J R Arch; D R Buckle; J F Taylor
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

8.  Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea.

Authors:  S J Ireland; F Bailey; A Cook; R M Hagan; C C Jordan; M L Stephens-Smith
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

9.  Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands.

Authors:  Juan P Ianowski; Jae Young Choi; Jeffrey J Wine; John W Hanrahan
Journal:  Pflugers Arch       Date:  2008-05-29       Impact factor: 3.657

10.  Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences.

Authors:  M G Belvisi; R Patacchini; P J Barnes; C A Maggi
Journal:  Br J Pharmacol       Date:  1994-01       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.