| Literature DB >> 24835104 |
Chenhui Hao1, Xiang Li1, Cheng Tian1, Wen Jiang2, Guansong Wang3, Chengde Mao4.
Abstract
RNA nanotechnology promises rational design of RNA nanostructures with wide array of structural diversities and functionalities. Such nanostructures could be used in applications such as small interfering RNA delivery and organization of in vivo chemical reactions. Though having impressive development in recent years, RNA nanotechnology is still quite limited and its programmability and complexity could not rival the degree of its closely related cousin: DNA nanotechnology. Novel strategies are needed for programmed RNA self-assembly. Here, we have assembled RNA nanocages by re-engineering a natural, biological RNA motif: the packaging RNA of phi29 bacteriophage. The resulting RNA nanostructures have been thoroughly characterized by gel electrophoresis, cryogenic electron microscopy imaging and dynamic light scattering.Entities:
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Year: 2014 PMID： 24835104 DOI： 10.1038/ncomms4890
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919