CONCLUSION: Risk factors associated with increased carriage rates are the same in children with recurrent acute otitis media (rAOM) as in healthy children. These are also known to be risk factors for the development of AOM itself. OBJECTIVES: The aim of this study was to describe risk factors for nasopharyngeal carriage in a cohort of young children at high risk of developing rAOM. METHODS:Children with an onset of AOM before 6 months of age, indicating an 80% risk of developing rAOM, were enrolled in a vaccination trial on heptavalent PCV. These children were monitored for 3 years during healthy and AOM periods with nasopharyngeal cultures, physical examinations, and questionnaires. RESULTS:A total of 109 children were included at a mean age of 5 months; 105 were followed for 3 years, 89 (82%) of whom developed rAOM. Risk factors associated with increased carriage of all major AOM pathogens were age <2 years, concurrent AOM, and fulfilment of rAOM criteria. Having siblings in day care was associated with increased carriage of Streptococcus pneumoniae and Haemophilus influenzae, recent antibiotic treatment was associated with H. influenzae and Moraxella catarrhalis carriage, and winter season was associated with M. catarrhalis carriage alone.
RCT Entities:
CONCLUSION: Risk factors associated with increased carriage rates are the same in children with recurrent acute otitis media (rAOM) as in healthy children. These are also known to be risk factors for the development of AOM itself. OBJECTIVES: The aim of this study was to describe risk factors for nasopharyngeal carriage in a cohort of young children at high risk of developing rAOM. METHODS:Children with an onset of AOM before 6 months of age, indicating an 80% risk of developing rAOM, were enrolled in a vaccination trial on heptavalent PCV. These children were monitored for 3 years during healthy and AOM periods with nasopharyngeal cultures, physical examinations, and questionnaires. RESULTS: A total of 109 children were included at a mean age of 5 months; 105 were followed for 3 years, 89 (82%) of whom developed rAOM. Risk factors associated with increased carriage of all major AOM pathogens were age <2 years, concurrent AOM, and fulfilment of rAOM criteria. Having siblings in day care was associated with increased carriage of Streptococcus pneumoniae and Haemophilus influenzae, recent antibiotic treatment was associated with H. influenzae and Moraxella catarrhalis carriage, and winter season was associated with M. catarrhalis carriage alone.
Entities:
Keywords:
Haemophilus influenzae; Moraxella catarrhalis; Otitis-prone children; Streptococcus pneumoniae; day care; nasopharyngeal carriage; nasopharyngeal colonization; rAOM; season
Authors: Shu Mei Teo; Danny Mok; Kym Pham; Merci Kusel; Michael Serralha; Niamh Troy; Barbara J Holt; Belinda J Hales; Michael L Walker; Elysia Hollams; Yury A Bochkov; Kristine Grindle; Sebastian L Johnston; James E Gern; Peter D Sly; Patrick G Holt; Kathryn E Holt; Michael Inouye Journal: Cell Host Microbe Date: 2015-04-09 Impact factor: 21.023
Authors: Luke V Blakeway; Aimee Tan; Rachael Lappan; Amir Ariff; Janessa L Pickering; Christopher S Peacock; Christopher C Blyth; Charlene M Kahler; Barbara J Chang; Deborah Lehmann; Lea-Ann S Kirkham; Timothy F Murphy; Michael P Jennings; Lauren O Bakaletz; John M Atack; Ian R Peak; Kate L Seib Journal: Genome Biol Evol Date: 2018-11-01 Impact factor: 3.416