OBJECTIVE: Our objective was to assess whether self-reported adverse life events during childhood or over the lifespan are associated with altered activity of the autonomic nervous system (ANS), the hypothalamic-pituitary-adrenal axis (HPA axis), and the immune system. METHOD: This study was performed in a population-based cohort of 1094 adults aged 33-79 years, 46.3% male, average age 53 (SD 11.4). Two waves of data were collected at a 2-year interval, enabling replication of the analyses. Cumulative exposure to adverse life events was assessed by means of the List of Threatening Experiences. ANS function was assessed by spectral analysis of heart rate variability in the high-frequency band (HRV-HF). HPA axis function was assessed by 24-h urinary free cortisol (24-h UFC) excretion. Inflammation was assessed by high-sensitive C-reactive protein (hsCRP). RESULTS: Multiple linear regression analyses did not reveal any significant associations, with the exception of one significant negative association between the lifetime score of adverse life events and HRV-HF β = -0.028; P = 0.037 at baseline, but not at follow up 2 years later. CONCLUSION: In a large population-based cohort, adverse life events were not consistently associated with HRV-HF, 24-h UFC or (hsCRP).
OBJECTIVE: Our objective was to assess whether self-reported adverse life events during childhood or over the lifespan are associated with altered activity of the autonomic nervous system (ANS), the hypothalamic-pituitary-adrenal axis (HPA axis), and the immune system. METHOD: This study was performed in a population-based cohort of 1094 adults aged 33-79 years, 46.3% male, average age 53 (SD 11.4). Two waves of data were collected at a 2-year interval, enabling replication of the analyses. Cumulative exposure to adverse life events was assessed by means of the List of Threatening Experiences. ANS function was assessed by spectral analysis of heart rate variability in the high-frequency band (HRV-HF). HPA axis function was assessed by 24-h urinary free cortisol (24-h UFC) excretion. Inflammation was assessed by high-sensitive C-reactive protein (hsCRP). RESULTS: Multiple linear regression analyses did not reveal any significant associations, with the exception of one significant negative association between the lifetime score of adverse life events and HRV-HF β = -0.028; P = 0.037 at baseline, but not at follow up 2 years later. CONCLUSION: In a large population-based cohort, adverse life events were not consistently associated with HRV-HF, 24-h UFC or (hsCRP).
Authors: Ye Ji Kim; Oleksiy M Levantsevych; Lisa Elon; Tené T Lewis; Shakira F Suglia; J Douglas Bremner; Arshed A Quyyumi; Bradley Pearce; Paolo Raggi; Viola Vaccarino; Amit J Shah Journal: J Trauma Stress Date: 2022-01-15
Authors: Irene Tung; Robert T Krafty; Meaghan L Delcourt; Nadine M Melhem; J Richard Jennings; Kate Keenan; Alison E Hipwell Journal: Psychophysiology Date: 2021-03-13 Impact factor: 4.348
Authors: Mary Princip; Marco Scholz; Rebecca E Meister-Langraf; Jürgen Barth; Ulrich Schnyder; Hansjörg Znoj; Jean-Paul Schmid; Julian F Thayer; Roland von Känel Journal: Front Psychol Date: 2016-11-18
Authors: Jeremy D Coplan; Anna V Rozenboym; Sasha L Fulton; Venkatesh Panthangi; Jean Tang; Lakshmi Thiramangalakdi; Tarique D Perera; Yang Liu; Haroon Kamran; Michael J Owens; Charles B Nemeroff; Leonard A Rosenblum; John G Kral; Louis Salciccioli; Jason Lazar Journal: Neurobiol Stress Date: 2017-01-03
Authors: Maryse J Bakema; Mirjam van Zuiden; Didier Collard; Jasper B Zantvoord; Susanne R de Rooij; Leonie K Elsenburg; Marieke B Snijder; Karien Stronks; Bert-Jan H van den Born; Anja Lok Journal: Front Psychiatry Date: 2020-03-17 Impact factor: 4.157
Authors: Harry Fisher; Marianne Jr Gittoes; Lynne Evans; C Leah Bitchell; Richard J Mullen; Marco Scutari Journal: Front Sports Act Living Date: 2020-12-14
Authors: David Bann; Rebecca Hardy; Rachel Cooper; Hany Lashen; Brian Keevil; Frederick C W Wu; Jeff M P Holly; Ken K Ong; Yoav Ben-Shlomo; Diana Kuh Journal: Soc Sci Med Date: 2015-11-06 Impact factor: 4.634