Literature DB >> 24832936

HSC senescence upon irradiation.

Hartmut Geiger1.   

Abstract

In this issue of Blood, Shao et al report that a side effect of total body irradiation (TBI) is long-term bone marrow injury and thus dysfunctional hematopoiesis caused by the induction of hematopoietic stem cell (HSC) senescence. Interestingly and unexpectedly, however, this happens in a manner independent of the cell-cycle regulators Ink4a and Arf, which play a major role in senescence in other cell systems.

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Year:  2014        PMID： 24832936      PMCID： PMC4023413          DOI： 10.1182/blood-2014-03-563718

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  8 in total

1.  Total body irradiation selectively induces murine hematopoietic stem cell senescence.

Authors:  Yong Wang; Bradley A Schulte; Amanda C LaRue; Makio Ogawa; Daohong Zhou
Journal:  Blood       Date:  2005-09-08       Impact factor: 22.113

2.  Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

Authors:  Viktor Janzen; Randolf Forkert; Heather E Fleming; Yoriko Saito; Michael T Waring; David M Dombkowski; Tao Cheng; Ronald A DePinho; Norman E Sharpless; David T Scadden
Journal:  Nature       Date:  2006-09-06       Impact factor: 49.962

3.  Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis.

Authors:  D H Christiansen; M K Andersen; J Pedersen-Bjergaard
Journal:  J Clin Oncol       Date:  2001-03-01       Impact factor: 44.544

4.  Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

Authors:  Søren M Johnson; Chad D Torrice; Jessica F Bell; Kimberly B Monahan; Qi Jiang; Yong Wang; Matthew R Ramsey; Jian Jin; Kwok-Kin Wong; Lishan Su; Daohong Zhou; Norman E Sharpless
Journal:  J Clin Invest       Date:  2010-06-23       Impact factor: 14.808

Review 5.  Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy.

Authors:  P Mauch; L Constine; J Greenberger; W Knospe; J Sullivan; J L Liesveld; H J Deeg
Journal:  Int J Radiat Oncol Biol Phys       Date:  1995-03-30       Impact factor: 7.038

6.  Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk.

Authors:  Liang Li; Min Li; Canlan Sun; Liton Francisco; Sujata Chakraborty; Melanie Sabado; Tinisha McDonald; Janelle Gyorffy; Karen Chang; Shirong Wang; Wenhong Fan; Jiangning Li; Lue Ping Zhao; Jerald Radich; Stephen Forman; Smita Bhatia; Ravi Bhatia
Journal:  Cancer Cell       Date:  2011-11-15       Impact factor: 31.743

7.  Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.

Authors:  Lijian Shao; Wei Feng; Hongliang Li; David Gardner; Yi Luo; Yong Wang; Lingbo Liu; Aimin Meng; Norman E Sharpless; Daohong Zhou
Journal:  Blood       Date:  2014-03-12       Impact factor: 22.113

8.  Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.

Authors:  Hartmut Geiger; Snehalata A Pawar; Edward J Kerschen; Kalpana J Nattamai; Irene Hernandez; Hai Po H Liang; Jose Á Fernández; Jose A Cancelas; Marnie A Ryan; Olga Kustikova; Axel Schambach; Qiang Fu; Junru Wang; Louis M Fink; Karl-Uwe Petersen; Daohong Zhou; John H Griffin; Christopher Baum; Hartmut Weiler; Martin Hauer-Jensen
Journal:  Nat Med       Date:  2012-07       Impact factor: 53.440
  8 in total
  1 in total

1.  Total body proton and heavy-ion irradiation causes cellular senescence and promotes pro-osteoclastogenic activity in mouse bone marrow.

Authors:  Kamendra Kumar; Kamal Datta; Albert J Fornace; Shubhankar Suman
Journal:  Heliyon       Date:  2021-12-29
  1 in total

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