Abebaw M Yohannes1, Gindo Tampubolon. 1. Department of Health Professions, Manchester Metropolitan University, Elizabeth Gaskell Campus, Hathersage Road, Manchester, M13 0JA, UK.
Abstract
BACKGROUND: Decline in lung function with increasing age is common in older people. However, the rate of decline using the forced expiratory volume in 1 s (FEV1) in a longitudinal study in the elderly community dwellers is unknown. METHODS: We analyzed data from the English Longitudinal Study of Ageing on people 50 years and older who had FEV1 measurement at Wave 2 and Wave 4 of 4 years of follow-up, respectively. A random coefficient model was employed to examine the changes in FEV1 and predict differences in the levels of FEV1 in older people. RESULTS: A total of 4224 participants were included in the study. The mean (± standard deviation [SD]) rate of change in FEV1 was a decline of 32.92 ± 0.96 ml/year. The absolute difference in mean FEV1 level between female and male participants was 767.07 ± 16.6 ml. It was 253.91 ± 22.7 ml lower in current smokers than in nonsmokers, 73.67 ± 18.67 ml lower in participants with a history of sputum in winter months than in participants without sputum, 63.32 ± 7.07 ml lower in participants with a higher dyspnea score than in participants with a lower dyspnea score and 67.77 ± 15.87 ml higher in participants with good health compared to participants with fair/poor health status. One microgram increase in C-reactive protein level lowered FEV1 by 4.66 ± 0.86 ml and one Hb of hemoglobin increased the FEV1 level by 4.78 ± 0.77 ml. All were statistically significant at p < 0.001. CONCLUSIONS: The average rate of FEV1 decline in older people without respiratory diseases was found to be high. Lower level of FEV1 was also observed in current smokers, females, those with a history of sputum in winter months and in participants with higher dyspnea score or in those with poorer health status.
BACKGROUND: Decline in lung function with increasing age is common in older people. However, the rate of decline using the forced expiratory volume in 1 s (FEV1) in a longitudinal study in the elderly community dwellers is unknown. METHODS: We analyzed data from the English Longitudinal Study of Ageing on people 50 years and older who had FEV1 measurement at Wave 2 and Wave 4 of 4 years of follow-up, respectively. A random coefficient model was employed to examine the changes in FEV1 and predict differences in the levels of FEV1 in older people. RESULTS: A total of 4224 participants were included in the study. The mean (± standard deviation [SD]) rate of change in FEV1 was a decline of 32.92 ± 0.96 ml/year. The absolute difference in mean FEV1 level between female and male participants was 767.07 ± 16.6 ml. It was 253.91 ± 22.7 ml lower in current smokers than in nonsmokers, 73.67 ± 18.67 ml lower in participants with a history of sputum in winter months than in participants without sputum, 63.32 ± 7.07 ml lower in participants with a higher dyspnea score than in participants with a lower dyspnea score and 67.77 ± 15.87 ml higher in participants with good health compared to participants with fair/poor health status. One microgram increase in C-reactive protein level lowered FEV1 by 4.66 ± 0.86 ml and one Hb of hemoglobin increased the FEV1 level by 4.78 ± 0.77 ml. All were statistically significant at p < 0.001. CONCLUSIONS: The average rate of FEV1 decline in older people without respiratory diseases was found to be high. Lower level of FEV1 was also observed in current smokers, females, those with a history of sputum in winter months and in participants with higher dyspnea score or in those with poorer health status.
Entities:
Keywords:
COPD; ELSA; FEV1; longitudinal study; lung function; older people
Authors: Shilpa Dogra; Joshua Good; Matthew P Buman; Paul A Gardiner; Michael K Stickland; Jennifer L Copeland Journal: BMC Public Health Date: 2018-07-03 Impact factor: 3.295
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