Literature DB >> 24831324

Topical pharmacotherapy for skin cancer: part I. Pharmacology.

Giuseppe Micali1, Francesco Lacarrubba2, Maria Rita Nasca2, Robert A Schwartz3.   

Abstract

Topical pharmacotherapy represents an effective alternative treatment for superficial skin cancer, primarily actinic keratoses and basal cell carcinomas. We provide an in-depth analysis of the pharmacologic aspects of available topical drugs for the treatment of primary skin tumors. In particular, we evaluate the mechanisms of action, formulations and indications, side effects, and contraindications of 5-fluorouracil, imiquimod, diclofenac, ingenol mebutate, and retinoids. Moreover, the characteristics of some investigational molecules (ie, resiquimod, piroxicam, dobesilate, and betulinic acid) are presented.
Copyright © 2014 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Entities:  

Keywords:  5-fluorouracil; betulinic acid; diclofenac; dobesilate; imiquimod; ingenol mebutate; piroxicam; resiquimod; retinoids; skin cancer

Mesh：

Substances：

Year:  2014        PMID： 24831324     DOI： 10.1016/j.jaad.2013.12.045

Source DB:  PubMed          Journal:  J Am Acad Dermatol        ISSN： 0190-9622            Impact factor:   11.527


  13 in total

Review 1.  Basal Cell Carcinoma: A Comprehensive Review of Existing and Emerging Nonsurgical Therapies.

Authors:  Julien Lanoue; Gary Goldenberg
Journal:  J Clin Aesthet Dermatol       Date:  2016-05-01

2.  The molecular mechanisms of vulpinic acid induced programmed cell death in melanoma.

Authors:  Sevcan Yangın; Demet Cansaran-Duman; Gamze Guney Eskiler; Sümer Aras
Journal:  Mol Biol Rep       Date:  2022-08-12       Impact factor: 2.742

Review 3.  Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?

Authors:  T J Mitchison; J Pineda; J Shi; S Florian
Journal:  Open Biol       Date:  2017-11       Impact factor: 6.411

4.  Ingenol mebutate in low amounts for the treatment of actinic keratosis in Korean patients.

Authors:  Hyun Jae Joe; Byung Ho Oh
Journal:  Clin Cosmet Investig Dermatol       Date:  2017-03-30

5.  Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy.

Authors:  Naoto Nishii; Hidetake Tachinami; Yuta Kondo; Yulong Xia; Yoshihisa Kashima; Tatsukuni Ohno; Shigenori Nagai; Lixin Li; Walter Lau; Hiroyuki Harada; Miyuki Azuma
Journal:  Oncotarget       Date:  2018-01-27

6.  Anti-cancer activity of ZnO chips by sustained zinc ion release.

Authors:  Seong-Hee Moon; Won Jin Choi; Sik-Won Choi; Eun Hye Kim; Jiyeon Kim; Jeong-O Lee; Seong Hwan Kim
Journal:  Toxicol Rep       Date:  2016-03-19

Review 7.  Topical Therapy for non-invasive penile cancer (Tis)-updated results and toxicity.

Authors:  Aditya Manjunath; Thomas Brenton; Sarah Wylie; Catherine M Corbishley; Nick A Watkin
Journal:  Transl Androl Urol       Date:  2017-10

8.  Factors influencing response to ingenol mebutate therapy for actinic keratosis of face and scalp.

Authors:  Nevena Skroza; Ilaria Proietti; Nicoletta Bernardini; Veronica Balduzzi; Alessandra Mambrin; Anna Marchesiello; Ersilia Tolino; Sara Zuber; Giuseppe La Torre; Concetta Potenza
Journal:  World J Clin Oncol       Date:  2017-10-10

Review 9.  Updates on the Management of Non-Melanoma Skin Cancer (NMSC).

Authors:  Artur Fahradyan; Anna C Howell; Erik M Wolfswinkel; Michaela Tsuha; Parthiv Sheth; Alex K Wong
Journal:  Healthcare (Basel)       Date:  2017-11-01

10.  The effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment.

Authors:  Tatsiana Damps; Anna Katarzyna Laskowska; Tomasz Kowalkowski; Monika Prokopowicz; Anna Katarzyna Puszko; Piotr Sosnowski; Joanna Czuwara; Marek Konop; Krzysztof Różycki; Joanna Karolina Borkowska; Aleksandra Misicka; Lidia Rudnicka
Journal:  PLoS One       Date:  2017-08-31       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.