Billur Cosan Sarbay1, Gozde Kir2, Cumhur Selcuk Topal2, Eyup Gumus3. 1. Pathology Department, Umraniye Education and Research Hospital, Istanbul, Turkey. Electronic address: billurcosan@hotmail.com. 2. Pathology Department, Umraniye Education and Research Hospital, Istanbul, Turkey. 3. Urology Department, Umraniye Education and Research Hospital, Istanbul, Turkey.
Abstract
INTRODUCTION: There is now increased understanding that invasive cribriform carcinoma is a relatively aggressive disease. In some recent publications, the recommendation is that all cribriform patterns be classified as Gleason pattern (GP) 4 rather than GP 3. MATERIALS AND METHODS: We assessed the cribriform foci (CF) associated with the more definitive patterns 3, 4, and 5 elsewhere on the 185 radical prostatectomy specimens and evaluated the association of the cribriform pattern with extraprostatic extension, surgical margin. RESULTS: CF were more frequently observed in cases with definitive patterns 4 and 5 than in cases with pattern 3 (all cases with pattern 5 exhibited CF). Cases with Gleason score 3+3 and CF were more frequently associated with extraprostatic extension, and a positive surgical margin. CONCLUSIONS: Our results demonstrate that diagnosing all cribriform patterns as at least GP 4 would significantly affect further therapeutic options and prognosis. However, as many of these modifications are empirical and supported by only a few studies, long-term follow-up studies with clinical endpoints are necessary to validate these recommendations.
INTRODUCTION: There is now increased understanding that invasive cribriform carcinoma is a relatively aggressive disease. In some recent publications, the recommendation is that all cribriform patterns be classified as Gleason pattern (GP) 4 rather than GP 3. MATERIALS AND METHODS: We assessed the cribriform foci (CF) associated with the more definitive patterns 3, 4, and 5 elsewhere on the 185 radical prostatectomy specimens and evaluated the association of the cribriform pattern with extraprostatic extension, surgical margin. RESULTS: CF were more frequently observed in cases with definitive patterns 4 and 5 than in cases with pattern 3 (all cases with pattern 5 exhibited CF). Cases with Gleason score 3+3 and CF were more frequently associated with extraprostatic extension, and a positive surgical margin. CONCLUSIONS: Our results demonstrate that diagnosing all cribriform patterns as at least GP 4 would significantly affect further therapeutic options and prognosis. However, as many of these modifications are empirical and supported by only a few studies, long-term follow-up studies with clinical endpoints are necessary to validate these recommendations.
Authors: Antonio Ieni; Giuseppe Angelico; Valeria Barresi; Giuseppe Giuffrè; Francesco Arena; Rosario Alberto Caruso; Giovanni Tuccari Journal: Dis Markers Date: 2018-02-18 Impact factor: 3.434
Authors: Eva Hollemans; Esther I Verhoef; Chris H Bangma; John Rietbergen; Jozien Helleman; Monique J Roobol; Geert J L H van Leenders Journal: Mod Pathol Date: 2018-10-22 Impact factor: 7.842
Authors: Eva Hollemans; Esther I Verhoef; Chris H Bangma; John Rietbergen; Monique J Roobol; Jozien Helleman; Geert J L H van Leenders Journal: Histopathology Date: 2020-04 Impact factor: 5.087