| Literature DB >> 24831057 |
Elizabeth Perry1, Clive Kelly2, Paul Eggleton3, Anthony De Soyza3, David Hutchinson2.
Abstract
Recent findings have highlighted the potential initiation of ACPA in sites away from the joint. Periodontitis is an example of this concept. This process in the gums appears to be independent of smoking, the main environmental risk factor for ACPA-positive RA. There is extensive literature regarding the potential role of smoking in the pathogenesis of ACPA-positive RA. As a consequence of this strong association, the lung has become the focus of research to determine whether processes within the lung are linked to the generation of ACPA. Here we outline the current body of evidence and explore the hypothesis that the lung as an organ of immune defence has a role in the pathogenesis of the autoimmune disease ACPA-positive RA.Entities:
Keywords: anti-citrullinated protein/peptide antibodies; autoimmunity; bronchiectasis; cigarette smoking; infection; interstitial lung disease; pathogenesis; rheumatoid arthritis; rheumatoid factor
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Year: 2014 PMID： 24831057 DOI： 10.1093/rheumatology/keu195
Source DB: PubMed Journal: Rheumatology (Oxford) ISSN： 1462-0324 Impact factor: 7.580