| Literature DB >> 24829140 |
Guoliang Yang1, Lianhua Zhang, Shilong Lin, Linfeng Li, Mengyao Liu, Haige Chen, Ming Cao, Dongming Liu, Yi-Ran Huang, Juanjie Bo.
Abstract
Astrocyte elevated gene-1 (AEG-1), a novel oncoprotein, has been implicated in oncogenesis and cancer progression in various types of human cancers. Here, immunohistochemistry was used to detect AEG-1 expression in nonmuscle-invasive bladder cancer (NMIBC), and these data were examined for correlation with clinicopathological parameters, and prognosis. Immunohistochemical analysis revealed that AEG-1 expression was significantly higher in bladder cancer tissues than that in normal tissues. High expression of AEG-1 was found in 45 % of bladder cancers and significantly associated with tumor grade (P = 0.002) and progression (P = 0.028). The Kaplan-Meier survival analysis demonstrated that AEG-1 expression was significantly associated with shorter progression-free survival (P = 0.0011). Multivariate analysis further demonstrated that AEG-1 was an independent prognostic factor for patients with BC. AEG-1 protein may contribute to the malignant progression of bladder cancer, and present as a novel marker to predict the progression of NMIBC.Entities:
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Year: 2014 PMID： 24829140 DOI： 10.1007/s12032-014-0986-4
Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064