In Sun Ryu1, Jong-Lyel Roh2, Kyung-Ja Cho3, Seung-Ho Choi2, Soon Yuhl Nam2, Sang Yoon Kim2,4. 1. Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea. 2. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 3. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 4. Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Abstract
BACKGROUND: We examined the prognostic value of lymph node density in predicting cancer-specific mortality (CSM) for patients with lymph nodes positive (pN+) laryngeal squamous cell carcinoma (SCC) after laryngectomy. METHODS: The records of 156 patients with laryngeal SCC who initially underwent curative resection of the primary tumor combined with neck dissection were reviewed. RESULTS: The 5-year cumulative incidence of CSM was 20.4%. N classification and extralaryngeal spread (ELS) were independent variables for CSM in all patients. Univariate analyses in 71 pN+ patients showed that ELS, number of positive lymph nodes >4, and lymph node density >0.044 were significantly associated with increased CSM, whereas pN classification was not (p = .218). On multivariate analysis, lymph node density ≥0.044 remained an independent predictor of CSM (p = .001). CONCLUSION: Among the pN+ patients with laryngeal SCC, no pN classification but lymph node density was noted to have an independent impact on CSM.
BACKGROUND: We examined the prognostic value of lymph node density in predicting cancer-specific mortality (CSM) for patients with lymph nodes positive (pN+) laryngeal squamous cell carcinoma (SCC) after laryngectomy. METHODS: The records of 156 patients with laryngeal SCC who initially underwent curative resection of the primary tumor combined with neck dissection were reviewed. RESULTS: The 5-year cumulative incidence of CSM was 20.4%. N classification and extralaryngeal spread (ELS) were independent variables for CSM in all patients. Univariate analyses in 71 pN+ patients showed that ELS, number of positive lymph nodes >4, and lymph node density >0.044 were significantly associated with increased CSM, whereas pN classification was not (p = .218). On multivariate analysis, lymph node density ≥0.044 remained an independent predictor of CSM (p = .001). CONCLUSION: Among the pN+ patients with laryngeal SCC, no pN classification but lymph node density was noted to have an independent impact on CSM.
Authors: Vasu Divi; Jonathan Harris; Paul M Harari; Jay S Cooper; Jonathan McHugh; Diana Bell; Erich M Sturgis; Anthony J Cmelak; Mohan Suntharalingam; David Raben; Harold Kim; Sharon A Spencer; George E Laramore; Andy Trotti; Robert L Foote; Christopher Schultz; Wade L Thorstad; Qiang Ed Zhang; Quynh Thu Le; F Christopher Holsinger Journal: Cancer Date: 2016-07-15 Impact factor: 6.860