Literature DB >> 2482785

Substance P and bradykinin hyperpolarize pig coronary artery endothelial cells in primary culture.

P C Brunet1, J L Bény.   

Abstract

Substance P (SP) and bradykinin (BK) relax and hyperpolarize smooth muscles of pig coronary arteries in an endothelium-dependent manner. We investigated the effect of both peptides on the membrane potential of endothelial cells in culture. The membrane potential of pig coronary artery endothelial cells in primary culture was -44 mV. SP and BK hyperpolarized it transiently by 23 mV. These hyperpolarizations were dependent on the potassium gradient across the cellular membrane. They had similar time courses as the SP and BK endothelium-dependent hyperpolarizations already observed in smooth muscles.

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Year:  1989        PMID： 2482785     DOI： 10.1159/000158770

Source DB:  PubMed          Journal:  Blood Vessels        ISSN： 0303-6847


  15 in total

1.  Effect of substance P on the membrane potential of coronary arterial endothelial cells in situ.

Authors:  J L Bény
Journal:  Agents Actions       Date:  1990-11

2.  Substance P and bradykinin activate different types of KCa currents to hyperpolarize cultured porcine coronary artery endothelial cells.

Authors:  M Frieden; M Sollini; J Beny
Journal:  J Physiol       Date:  1999-09-01       Impact factor: 5.182

3.  An evaluation of potassium ions as endothelium-derived hyperpolarizing factor in porcine coronary arteries.

Authors:  J L Bény; O Schaad
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

4.  Acetylcholine-induced membrane potential changes in endothelial cells of rabbit aortic valve.

Authors:  M Ohashi; K Satoh; T Itoh
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

5.  Charybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells.

Authors:  M Sollini; M Frieden; J-L Bény
Journal:  Br J Pharmacol       Date:  2002-08       Impact factor: 8.739

6.  Effect of 5-hydroxytryptamine on the membrane potential of endothelial and smooth muscle cells in the pig coronary artery.

Authors:  M Frieden; J L Bény
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

7.  Modelling the electrophysiological endothelial cell response to bradykinin.

Authors:  Alexander Schuster; Jean-Louis Bény; Jean-Jacques Meister
Journal:  Eur Biophys J       Date:  2003-02-20       Impact factor: 1.733

8.  Functional electrical properties of the endothelium in lymphatic vessels of the guinea-pig mesentery.

Authors:  P Y von der Weid; D F Van Helden
Journal:  J Physiol       Date:  1997-10-15       Impact factor: 5.182

9.  Differences in the K(+)-channels opened by cromakalim, acetylcholine and substance P in rat aorta and porcine coronary artery.

Authors:  K Bray; U Quast
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739

10.  An intercellular regenerative calcium wave in porcine coronary artery endothelial cells in primary culture.

Authors:  A A Domenighetti; J L Bény; F Chabaud; M Frieden
Journal:  J Physiol       Date:  1998-11-15       Impact factor: 5.182
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