Tingting Yao1, Zhuna Wu2, Yukun Liu3, Qunxian Rao3, Zhongqiu Lin4. 1. Department of Gynaecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China Key Laboratory of Malignant Tumour Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University, Guangzhou, Guangdong Province, China. 2. Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China. 3. Department of Gynaecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China. 4. Department of Gynaecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China linzhongqiu@hotmail.com.
Abstract
OBJECTIVE: To analyse the associations between aldehyde dehydrogenase 1 (ALDH1) tumour immunopositivity and disease-free survival in cervical carcinoma. METHODS: ALDH1 immunohistochemistry was performed on formalin-fixed, paraffin wax-embedded cervical tumour tissue samples obtained from hospital archives. Data regarding disease-free survival were obtained. Kaplan-Meier survival analyses and Cox proportional hazards regression models were performed. RESULTS: Patients with ALDH1-positive tumours (n = 31) had significantly shorter disease-free survival than those with ALDH1-negative tumours (n = 167; 41.99 ± 0.90 vs 53.64 ± 2.67 months). ALDH1 positivity was associated with poor prognosis (relative risk 2.727; 95% confidence intervals 1.253, 5.914). CONCLUSIONS: ALDH1 positivity is associated with poor prognosis of cervical carcinoma, and may be an independent predictor of prognosis.
OBJECTIVE: To analyse the associations between aldehyde dehydrogenase 1 (ALDH1) tumour immunopositivity and disease-free survival in cervical carcinoma. METHODS:ALDH1 immunohistochemistry was performed on formalin-fixed, paraffin wax-embedded cervical tumour tissue samples obtained from hospital archives. Data regarding disease-free survival were obtained. Kaplan-Meier survival analyses and Cox proportional hazards regression models were performed. RESULTS:Patients with ALDH1-positive tumours (n = 31) had significantly shorter disease-free survival than those with ALDH1-negative tumours (n = 167; 41.99 ± 0.90 vs 53.64 ± 2.67 months). ALDH1 positivity was associated with poor prognosis (relative risk 2.727; 95% confidence intervals 1.253, 5.914). CONCLUSIONS:ALDH1 positivity is associated with poor prognosis of cervical carcinoma, and may be an independent predictor of prognosis.
Authors: Niyati Sudhalkar; Nidul P Rathod; Ashwathi Mathews; Supriya Chopra; Harshini Sriram; Shyam K Shrivastava; Jayant S Goda Journal: Cancer Rep (Hoboken) Date: 2018-11-08