BACKGROUND: Extracorporeal support (ECS) during organ procurement from donors after circulatory determination of death (DCDD) could increase the number of donor organs and decrease posttransplant complications. This study reports the experience of a large transplant center with controlled DCDD. METHODS: A retrospective review of all potential controlled-DCDD cases between October 1, 2000 and July 31, 2013 was performed. We focused on methods, ethical and practical issues, and recipient outcome data of organs procured and transplanted in our institution using ECS-assisted DCDD (E-DCDD). RESULTS: ECS was used for organ procurement in 37 controlled DCDD. The number of organs procured per donor was 2.59, and the number of organs transplanted per donor was 1.68. Delayed graft function occurred in 31% of renal grafts. In three donors (8%), organ donation was not completed because of surgeon judgment. Forty-eight renal grafts (65.8%), thirteen livers (61.9%), and one pancreas (50%) were successfully transplanted. CONCLUSIONS: ECS can be routinely implemented in controlled DCDD. In our experience, the organs provided per donor was 2.59. Widely applied, EDCDD could result in more donor organs, especially when applied to DCDD in uncontrolled conditions.
BACKGROUND: Extracorporeal support (ECS) during organ procurement from donors after circulatory determination of death (DCDD) could increase the number of donor organs and decrease posttransplant complications. This study reports the experience of a large transplant center with controlled DCDD. METHODS: A retrospective review of all potential controlled-DCDD cases between October 1, 2000 and July 31, 2013 was performed. We focused on methods, ethical and practical issues, and recipient outcome data of organs procured and transplanted in our institution using ECS-assisted DCDD (E-DCDD). RESULTS: ECS was used for organ procurement in 37 controlled DCDD. The number of organs procured per donor was 2.59, and the number of organs transplanted per donor was 1.68. Delayed graft function occurred in 31% of renal grafts. In three donors (8%), organ donation was not completed because of surgeon judgment. Forty-eight renal grafts (65.8%), thirteen livers (61.9%), and one pancreas (50%) were successfully transplanted. CONCLUSIONS: ECS can be routinely implemented in controlled DCDD. In our experience, the organs provided per donor was 2.59. Widely applied, EDCDD could result in more donor organs, especially when applied to DCDD in uncontrolled conditions.
Authors: David S Demos; Amit Iyengar; Benjamin S Bryner; Brian W Gray; Hayley R Hoffman; Marie S Cornell; John E Wilkinson; Daniel E Mazur; Robert H Bartlett; Jeffrey D Punch; Alvaro Rojas-Peña Journal: ASAIO J Date: 2015 Jul-Aug Impact factor: 2.872
Authors: Matthew J Weiss; Laura Hornby; Bram Rochwerg; Michael van Manen; Sonny Dhanani; V Ben Sivarajan; Amber Appleby; Mary Bennett; Daniel Buchman; Catherine Farrell; Aviva Goldberg; Rebecca Greenberg; Ram Singh; Thomas A Nakagawa; William Witteman; Jill Barter; Allon Beck; Kevin Coughlin; Alf Conradi; Cynthia Cupido; Rosanne Dawson; Anne Dipchand; Darren Freed; Karen Hornby; Valerie Langlois; Cheryl Mack; Meagan Mahoney; Deepak Manhas; Christopher Tomlinson; Samara Zavalkoff; Sam D Shemie Journal: Pediatr Crit Care Med Date: 2017-11 Impact factor: 3.624
Authors: Thomas Prudhomme; John F Mulvey; Liam A J Young; Benoit Mesnard; Maria Letizia Lo Faro; Ann Etohan Ogbemudia; Fungai Dengu; Peter J Friend; Rutger Ploeg; James P Hunter; Julien Branchereau Journal: Int J Mol Sci Date: 2021-05-13 Impact factor: 5.923
Authors: Patricia Ramirez; David Vázquez; Gabriel Rodríguez; Juan José Rubio; Marina Pérez; Jose Maria Portolés; Joaquín Carballido Journal: Transplant Direct Date: 2021-07-16
Authors: Stein Foss; Espen Nordheim; Dag W Sørensen; Torgunn B Syversen; Karsten Midtvedt; Anders Åsberg; Thorleif Dahl; Per A Bakkan; Aksel E Foss; Odd R Geiran; Arnt E Fiane; Pål-Dag Line Journal: Transplant Direct Date: 2018-06-13