Literature DB >> 24825059

Crossing the barrier: STRA6 in epidermal differentiation.

Kristian B Laursen1, Lorraine J Gudas2.   

Abstract

In this issue, Skazik et al. demonstrate that the STRA6 retinol transporter protein regulates the proliferation and differentiation of epidermal keratinocytes. In human organotypic three-dimensional skin and skin reconstitution models, depletion of STRA6 induced hyperproliferation-associated differentiation, resulting in epidermal expansion. This reveals that STRA6 functions as a "gatekeeper" in retinol (vitamin A)-mediated differentiation of human skin.

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Year:  2014        PMID： 24825059     DOI： 10.1038/jid.2014.49

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  10 in total

1.  The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.

Authors:  Daniel C Berry; Hugues Jacobs; Gurdeep Marwarha; Aurore Gely-Pernot; Sheila M O'Byrne; David DeSantis; Muriel Klopfenstein; Betty Feret; Christine Dennefeld; William S Blaner; Colleen M Croniger; Manuel Mark; Noa Noy; Norbert B Ghyselinck
Journal:  J Biol Chem       Date:  2013-07-09       Impact factor: 5.157

2.  Mutation analysis of the STRA6 gene in isolated and non-isolated anophthalmia/microphthalmia.

Authors:  N Chassaing; N Ragge; A Kariminejad; A Buffet; S Ghaderi-Sohi; J Martinovic; P Calvas
Journal:  Clin Genet       Date:  2012-07-04       Impact factor: 4.438

3.  Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6.

Authors:  Alberto Ruiz; Manuel Mark; Hugues Jacobs; Muriel Klopfenstein; Jane Hu; Marcia Lloyd; Samer Habib; Chinatsu Tosha; Roxana A Radu; Norbert B Ghyselinck; Steven Nusinowitz; Dean Bok
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-05-17       Impact factor: 4.799

4.  Downregulation of STRA6 expression in epidermal keratinocytes leads to hyperproliferation-associated differentiation in both in vitro and in vivo skin models.

Authors:  Claudia Skazik; Philipp M Amann; Ruth Heise; Yvonne Marquardt; Katharina Czaja; Arianna Kim; Ralph Rühl; Peter Kurschat; Hans F Merk; David R Bickers; Jens M Baron
Journal:  J Invest Dermatol       Date:  2013-11-27       Impact factor: 8.551

5.  RARgamma acts as a tumor suppressor in mouse keratinocytes.

Authors:  Chang Feng Chen; Philippe Goyette; David Lohnes
Journal:  Oncogene       Date:  2004-07-08       Impact factor: 9.867

6.  Liver retinol transporter and receptor for serum retinol-binding protein (RBP4).

Authors:  Philomena Alapatt; Fangjian Guo; Susan M Komanetsky; Shuping Wang; Jinjin Cai; Ashot Sargsyan; Eduardo Rodríguez Díaz; Brandon T Bacon; Pratik Aryal; Timothy E Graham
Journal:  J Biol Chem       Date:  2012-10-26       Impact factor: 5.157

7.  RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells.

Authors:  Vasundhra Kashyap; Kristian B Laursen; Fabienne Brenet; Agnes J Viale; Joseph M Scandura; Lorraine J Gudas
Journal:  J Cell Sci       Date:  2012-12-21       Impact factor: 5.285

8.  Retinoic acid receptors and GATA transcription factors activate the transcription of the human lecithin:retinol acyltransferase gene.

Authors:  Kun Cai; Lorraine J Gudas
Journal:  Int J Biochem Cell Biol       Date:  2008-07-04       Impact factor: 5.085

Review 9.  Diverse actions of retinoid receptors in cancer prevention and treatment.

Authors:  Nigel P Mongan; Lorraine J Gudas
Journal:  Differentiation       Date:  2007-07-18       Impact factor: 3.880

10.  Vitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein.

Authors:  Ming Zhong; Riki Kawaguchi; Mariam Ter-Stepanian; Miki Kassai; Hui Sun
Journal:  PLoS One       Date:  2013-11-01       Impact factor: 3.240
  10 in total
  1 in total

Review 1.  Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6.

Authors:  Riki Kawaguchi; Ming Zhong; Miki Kassai; Mariam Ter-Stepanian; Hui Sun
Journal:  Membranes (Basel)       Date:  2015-08-28
  1 in total

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