| Literature DB >> 24825058 |
Andrew Johnston1, Johann E Gudjonsson2.
Abstract
IL-22 targets our external epithelial barriers, bolstering our defenses, and has long been implicated in the pathogenesis of psoriasis. Nikamo and colleagues (2014) identify a haplotype in the IL22 promoter with a strong association to juvenile-onset psoriasis and demonstrate that this risk variant is associated with increased IL-22 production by T cells. We explore the implications of this work.Entities:
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Year: 2014 PMID： 24825058 DOI： 10.1038/jid.2014.81
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551