Literature DB >> 2482460

Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.

C Dugovic1, A Wauquier, P A Janssen.   

Abstract

The effects of risperidone, a new antipsychotic with potent 5-hydroxytryptamine2 (5-HT2) and dopamine-D2 (DA-D2) antagonistic properties, were studied on sleep-wakefulness patterns in rats. Administration of low doses (0.01-0.16 mg/kg i.p.) resulted in a significant increase of deep slow wave sleep (SWS2) and a decrease of wakefulness (W) and light slow wave sleep (SWS1). High doses (0.63-2.5 mg/kg) produced opposite effects. Paradoxical sleep (PS) was significantly reduced over the dose range tested. The increase of SWS2 after low doses of risperidone could be related to a predominant and potent 5-HT2 receptor blocking activity.

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Year:  1989        PMID： 2482460     DOI： 10.1016/0028-3908(89)90023-3

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  6 in total

Review 1.  Risperidone: a review of its use in the management of the behavioural and psychological symptoms of dementia.

Authors:  N Bhana; C M Spencer
Journal:  Drugs Aging       Date:  2000-06       Impact factor: 3.923

2.  Effects of olanzapine, risperidone and haloperidol on sleep after a single oral morning dose in healthy volunteers.

Authors:  Sandra Giménez; Susana Clos; Sergio Romero; Eva Grasa; Adelaida Morte; Manuel J Barbanoj
Journal:  Psychopharmacology (Berl)       Date:  2007-01-05       Impact factor: 4.530

3.  Effects of typical antipsychotic drugs and risperidone on the quality of sleep in patients with schizophrenia: a pilot study.

Authors:  S M Dursun; J K Patel; J G Burke; M A Reveley
Journal:  J Psychiatry Neurosci       Date:  1999-09       Impact factor: 6.186

4.  Effects of remoxipride, a dopamine D-2 antagonist antipsychotic, on sleep-waking patterns and EEG activity in rats and rabbits.

Authors:  E Ongini; P Bo; S Dionisotti; M Trampus; F Savoldi
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

Review 5.  Survey on the pharmacodynamics of the new antipsychotic risperidone.

Authors:  A A Megens; F H Awouters; A Schotte; T F Meert; C Dugovic; C J Niemegeers; J E Leysen
Journal:  Psychopharmacology (Berl)       Date:  1994-02       Impact factor: 4.530

Review 6.  Risperidone. A review of its pharmacology and therapeutic potential in the treatment of schizophrenia.

Authors:  S Grant; A Fitton
Journal:  Drugs       Date:  1994-08       Impact factor: 9.546
  6 in total

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