Makoto Hoshino1, Junichi Ohtawa2, Kenta Akitsu2. 1. Department of Respiratory Medicine, Atami Hospital, International University of Health and Welfare, Atami, Japan. Electronic address: hoshino@iuhw.ac.jp. 2. Department of Radiology, Atami Hospital, International University of Health and Welfare, Atami, Japan.
Abstract
BACKGROUND: Asthma is characterized by chronic airway inflammation and remodeling. Levels of serum high-sensitivity C-reactive protein (hs-CRP) reflect airway eosinophilic inflammation. However, the relation between hs-CRP and the development of airway wall thickening remains unknown. OBJECTIVE: To evaluate whether serum hs-CRP is associated with airway geometry in asthma. METHODS: Forty-eight steroid-naive patients with asthma, 51 patients with asthma treated with inhaled corticosteroids, and 38 aged-matched healthy controls were studied cross-sectionally. Serum hs-CRP levels, lung function, and inflammatory cell counts in sputum were measured. Quantitative computed tomographic analysis of the apical segment of the right upper lobe was performed. RESULTS: Serum hs-CRP levels were significantly elevated in steroid-naive patients with asthma compared with controls and steroid-treated patients with asthma and were associated with airflow limitation. In steroid-naive patients, serum hs-CRP levels were correlated with airway wall thickness (r = 0.88, P < .001) and sputum eosinophil percentage (r = 0.75, P < .001). Multivariate analysis showed a significant association between hs-cRP levels and forced expiratory volume in 1 second (percentage predicted; R(2) = 0.65, P = .001). CONCLUSION: Serum hs-CRP may be a useful systemic biomarker of airway eosinophilia in steroid-naive asthma and has potential utility as a marker for the development of airway wall thickening. TRIAL REGISTRATION: University Hospital Medical Information Network (www.umin.ac.jp/ctr/index/htm); identifier, UMIN000006724.
BACKGROUND:Asthma is characterized by chronic airway inflammation and remodeling. Levels of serum high-sensitivity C-reactive protein (hs-CRP) reflect airway eosinophilic inflammation. However, the relation between hs-CRP and the development of airway wall thickening remains unknown. OBJECTIVE: To evaluate whether serum hs-CRP is associated with airway geometry in asthma. METHODS: Forty-eight steroid-naive patients with asthma, 51 patients with asthma treated with inhaled corticosteroids, and 38 aged-matched healthy controls were studied cross-sectionally. Serum hs-CRP levels, lung function, and inflammatory cell counts in sputum were measured. Quantitative computed tomographic analysis of the apical segment of the right upper lobe was performed. RESULTS: Serum hs-CRP levels were significantly elevated in steroid-naive patients with asthma compared with controls and steroid-treated patients with asthma and were associated with airflow limitation. In steroid-naive patients, serum hs-CRP levels were correlated with airway wall thickness (r = 0.88, P < .001) and sputum eosinophil percentage (r = 0.75, P < .001). Multivariate analysis showed a significant association between hs-cRP levels and forced expiratory volume in 1 second (percentage predicted; R(2) = 0.65, P = .001). CONCLUSION: Serum hs-CRP may be a useful systemic biomarker of airway eosinophilia in steroid-naive asthma and has potential utility as a marker for the development of airway wall thickening. TRIAL REGISTRATION: University Hospital Medical Information Network (www.umin.ac.jp/ctr/index/htm); identifier, UMIN000006724.
Authors: Sophia N Karagiannis; Aida Santaolalla; Sam Sollie; Ali Rislan; Debra H Josephs; Niklas Hammar; Goran Walldius; Hans Garmo; Mieke Van Hemelrijck Journal: BMC Immunol Date: 2021-09-06 Impact factor: 3.615
Authors: A Ra Ko; Yoon Hee Kim; In Suk Sol; Min Jung Kim; Seo Hee Yoon; Kyung Won Kim; Kyu-Earn Kim Journal: Yonsei Med J Date: 2016-05 Impact factor: 2.759