| Literature DB >> 24821373 |
Riccardo Sarzani1, Marica Bordicchia, Francesco Spannella, Paolo Dessì-Fulgheri, Massimiliano Fedecostante.
Abstract
The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular-metabolic syndrome, where an "handicap" of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.Entities:
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Year: 2014 PMID: 24821373 DOI: 10.1007/s40292-014-0054-3
Source DB: PubMed Journal: High Blood Press Cardiovasc Prev ISSN: 1120-9879