Literature DB >> 24820083

Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib by zinc: reversal of amikacin resistance in Acinetobacter baumannii and Escherichia coli by a zinc ionophore.

David L Lin1, Tung Tran1, Jamal Y Alam1, Steven R Herron1, Maria Soledad Ramirez2, Marcelo E Tolmasky3.   

Abstract

In vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by ZnCl2 with a 50% inhibitory concentration (IC50) of 15 μM. Growth of Acinetobacter baumannii or Escherichia coli harboring aac(6')-Ib in cultures containing 8 μg/ml amikacin was significantly inhibited by the addition of 2 μM Zn(2+) in complex with the ionophore pyrithione (ZnPT).
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24820083      PMCID： PMC4068593          DOI： 10.1128/AAC.00129-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

Review 1.  The missing zinc: p53 misfolding and cancer.

Authors:  Stewart N Loh
Journal:  Metallomics       Date:  2010-05-18       Impact factor: 4.526

Review 2.  Zinc: a multipurpose trace element.

Authors:  M Stefanidou; C Maravelias; A Dona; C Spiliopoulou
Journal:  Arch Toxicol       Date:  2005-09-27       Impact factor: 5.153

3.  Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria.

Authors:  Alfonso J C Soler Bistué; Fernando A Martín; Nicolás Vozza; Hongphuc Ha; Jonathan C Joaquín; Angeles Zorreguieta; Marcelo E Tolmasky
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-28       Impact factor: 11.205

4.  Cleavage of small peptides in vitro by human rhinovirus 14 3C protease expressed in Escherichia coli.

Authors:  M G Cordingley; R B Register; P L Callahan; V M Garsky; R J Colonno
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

5.  Characteristics of zinc transport by two bacterial cation diffusion facilitators from Ralstonia metallidurans CH34 and Escherichia coli.

Authors:  Andreas Anton; Annett Weltrowski; Christopher J Haney; Sylvia Franke; Gregor Grass; Christopher Rensing; Dietrich H Nies
Journal:  J Bacteriol       Date:  2004-11       Impact factor: 3.490

Review 6.  The significance of zinc for leukocyte biology.

Authors:  N Wellinghausen; L Rink
Journal:  J Leukoc Biol       Date:  1998-11       Impact factor: 4.962

7.  Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.

Authors:  Aartjan J W te Velthuis; Sjoerd H E van den Worm; Amy C Sims; Ralph S Baric; Eric J Snijder; Martijn J van Hemert
Journal:  PLoS Pathog       Date:  2010-11-04       Impact factor: 6.823

8.  Complete nucleotide sequence of Klebsiella pneumoniae multiresistance plasmid pJHCMW1.

Authors:  Renee Sarno; Glen McGillivary; David J Sherratt; Luis A Actis; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

9.  Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm.

Authors:  María S Ramirez; Nikolas Nikolaidis; Marcelo E Tolmasky
Journal:  Front Microbiol       Date:  2013-05-17       Impact factor: 5.640

Review 10.  Discovery of human zinc deficiency: its impact on human health and disease.

Authors:  Ananda S Prasad
Journal:  Adv Nutr       Date:  2013-03-01       Impact factor: 8.701
View more
  21 in total

1.  A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides.

Authors:  Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal:  Medchemcomm       Date:  2015-11-19       Impact factor: 3.597

2.  Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance by zinc complexed with clioquinol, an ionophore active against tumors and neurodegenerative diseases.

Authors:  Kevin Chiem; Fong Hue; Jesus Magallon; Marcelo E Tolmasky
Journal:  Int J Antimicrob Agents       Date:  2017-08-03       Impact factor: 5.283

3.  Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts.

Authors:  Yijia Li; Keith D Green; Brooke R Johnson; Sylvie Garneau-Tsodikova
Journal:  Antimicrob Agents Chemother       Date:  2015-05-04       Impact factor: 5.191

4.  Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives.

Authors:  Sylvie Garneau-Tsodikova; Kristin J Labby
Journal:  Medchemcomm       Date:  2015-09-21       Impact factor: 3.597

5.  A Drug Repositioning Approach Reveals that Streptococcus mutans Is Susceptible to a Diverse Range of Established Antimicrobials and Nonantibiotics.

Authors:  S Saputo; R C Faustoferri; R G Quivey
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

6.  Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance in Klebsiella pneumoniae by zinc and copper pyrithione.

Authors:  Kevin Chiem; Brooke A Fuentes; David L Lin; Tung Tran; Alexis Jackson; Maria S Ramirez; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2015-07-13       Impact factor: 5.191

7.  Inhibition of AAC(6')-Ib-mediated resistance to amikacin in Acinetobacter baumannii by an antisense peptide-conjugated 2',4'-bridged nucleic acid-NC-DNA hybrid oligomer.

Authors:  Christina Lopez; Brock A Arivett; Luis A Actis; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2015-07-13       Impact factor: 5.191

8.  Comparison of Antimicrobial and Antibiofilm Activity of Proflavine Co-crystallized with Silver, Copper, Zinc, and Gallium Salts.

Authors:  Andrii Lekhan; Cecilia Fiore; Oleksii Shemchuk; Fabrizia Grepioni; Dario Braga; Raymond J Turner
Journal:  ACS Appl Bio Mater       Date:  2022-08-15

9.  Identification of an Inhibitor of the Aminoglycoside 6'-N-Acetyltransferase type Ib [AAC(6')-Ib] by Glide Molecular Docking.

Authors:  Kevin Chiem; Saumya Jani; Brooke Fuentes; David L Lin; Madeline E Rasche; Marcelo E Tolmasky
Journal:  Medchemcomm       Date:  2015-11-03       Impact factor: 3.597

10.  Draft Genome of the Multidrug-Resistant Acinetobacter baumannii Strain A155 Clinical Isolate.

Authors:  Brock A Arivett; Steven E Fiester; David C Ream; Daniela Centrón; Maria S Ramírez; Marcelo E Tolmasky; Luis A Actis
Journal:  Genome Announc       Date:  2015-03-26
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.