Literature DB >> 24820036

Direct action of endocrine disrupting chemicals on human sperm.

Christian Schiffer1, Astrid Müller1, Dorte L Egeberg2, Luis Alvarez1, Christoph Brenker1, Anders Rehfeld2, Hanne Frederiksen2, Benjamin Wäschle1, U Benjamin Kaupp1, Melanie Balbach1, Dagmar Wachten1, Niels E Skakkebaek3, Kristian Almstrup2, Timo Strünker4.   

Abstract

Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.
© 2014 The Authors.

Entities:  

Keywords:  Ca2+ signalling; CatSper; endocrine disrupting chemical; human sperm

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Substances：

Year:  2014        PMID： 24820036      PMCID： PMC4196979          DOI： 10.15252/embr.201438869

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  40 in total

1.  A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.

Authors: 
Journal:  J Biomol Screen       Date:  1999

2.  CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.

Authors:  Anne E Carlson; Ruth E Westenbroek; Timothy Quill; Dejian Ren; David E Clapham; Bertil Hille; David L Garbers; Donner F Babcock
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

Review 3.  Genetic male infertility and mutation of CATSPER ion channels.

Authors:  Michael S Hildebrand; Matthew R Avenarius; Marc Fellous; Yuzhou Zhang; Nicole C Meyer; Jana Auer; Catherine Serres; Kimia Kahrizi; Hossein Najmabadi; Jacques S Beckmann; Richard J H Smith
Journal:  Eur J Hum Genet       Date:  2010-07-21       Impact factor: 4.246

4.  Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel.

Authors:  Yuriy Kirichok; Betsy Navarro; David E Clapham
Journal:  Nature       Date:  2006-02-09       Impact factor: 49.962

5.  Analysis of the direct effects of prostaglandins on human sperm function.

Authors:  R J Aitken; R W Kelly
Journal:  J Reprod Fertil       Date:  1985-01

6.  Levels of DDT and its metabolites in placenta, maternal and cord blood and their potential influence on neonatal anthropometric measures.

Authors:  Iman Al-Saleh; Inaam Al-Doush; Ammar Alsabbaheen; Gamal El Din Mohamed; Abdullah Rabbah
Journal:  Sci Total Environ       Date:  2011-12-20       Impact factor: 7.963

Review 7.  [Ca2+]i signalling in sperm--making the most of what you've got.

Authors:  Stephen Publicover; Claire V Harper; Christopher Barratt
Journal:  Nat Cell Biol       Date:  2007-03       Impact factor: 28.824

8.  Rheotaxis guides mammalian sperm.

Authors:  Kiyoshi Miki; David E Clapham
Journal:  Curr Biol       Date:  2013-02-28       Impact factor: 10.834

9.  Human male infertility caused by mutations in the CATSPER1 channel protein.

Authors:  Matthew R Avenarius; Michael S Hildebrand; Yuzhou Zhang; Nicole C Meyer; Luke L H Smith; Kimia Kahrizi; Hossein Najmabadi; Richard J H Smith
Journal:  Am J Hum Genet       Date:  2009-04-02       Impact factor: 11.025

10.  Parabens as urinary biomarkers of exposure in humans.

Authors:  Xiaoyun Ye; Amber M Bishop; John A Reidy; Larry L Needham; Antonia M Calafat
Journal:  Environ Health Perspect       Date:  2006-12       Impact factor: 9.031
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  38 in total

1.  Urinary concentrations of benzophenone-type ultraviolet radiation filters and couples' fecundity.

Authors:  Germaine M Buck Louis; Kurunthachalam Kannan; Katherine J Sapra; José Maisog; Rajeshwari Sundaram
Journal:  Am J Epidemiol       Date:  2014-11-13       Impact factor: 4.897

2.  Endocrine disrupting chemicals in seminal plasma and couple fecundity.

Authors:  Germaine M Buck Louis; Melissa M Smarr; Liping Sun; Zhen Chen; Masato Honda; Wei Wang; Rajendiran Karthikraj; Jennifer Weck; Kurunthachalam Kannan
Journal:  Environ Res       Date:  2018-02-22       Impact factor: 6.498

3.  Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban in an immigrant population in Brooklyn, New York.

Authors:  Laura A Geer; Benny F G Pycke; Joshua Waxenbaum; David M Sherer; Ovadia Abulafia; Rolf U Halden
Journal:  J Hazard Mater       Date:  2016-03-11       Impact factor: 10.588

4.  Action of steroids and plant triterpenoids on CatSper Ca2+ channels in human sperm.

Authors:  Christoph Brenker; Christian Schiffer; Isabel V Wagner; Frank Tüttelmann; Albrecht Röpke; Andreas Rennhack; U Benjamin Kaupp; Timo Strünker
Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-05       Impact factor: 11.205

5.  The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA.

Authors:  Tao Wang; Samuel Young; Henrike Krenz; Frank Tüttelmann; Albrecht Röpke; Claudia Krallmann; Sabine Kliesch; Xu-Hui Zeng; Christoph Brenker; Timo Strünker
Journal:  J Biol Chem       Date:  2020-07-23       Impact factor: 5.157

6.  The CatSper channel controls chemosensation in sea urchin sperm.

Authors:  Reinhard Seifert; Melanie Flick; Wolfgang Bönigk; Luis Alvarez; Christian Trötschel; Ansgar Poetsch; Astrid Müller; Normann Goodwin; Patric Pelzer; Nachiket D Kashikar; Elisabeth Kremmer; Jan Jikeli; Bernd Timmermann; Heiner Kuhl; Dmitry Fridman; Florian Windler; U Benjamin Kaupp; Timo Strünker
Journal:  EMBO J       Date:  2014-12-22       Impact factor: 11.598

7.  Gestational bisphenol A exposure and testis development.

Authors:  Cecilia Williams; Maria Bondesson; Dimitry N Krementsov; Cory Teuscher
Journal:  Endocr Disruptors (Austin)       Date:  2014

8.  Pesticide interactions and risks of sperm chromosomal abnormalities.

Authors:  Zaida I Figueroa; Heather A Young; Sunni L Mumford; John D Meeker; Dana B Barr; George M Gray; Melissa J Perry
Journal:  Int J Hyg Environ Health       Date:  2019-07-13       Impact factor: 5.840

9.  A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm.

Authors:  Andreas Rennhack; Christian Schiffer; Christoph Brenker; Dmitry Fridman; Elis T Nitao; Yi-Min Cheng; Lara Tamburrino; Melanie Balbach; Gabriel Stölting; Thomas K Berger; Michelina Kierzek; Luis Alvarez; Dagmar Wachten; Xu-Hui Zeng; Elisabetta Baldi; Stephen J Publicover; U Benjamin Kaupp; Timo Strünker
Journal:  Br J Pharmacol       Date:  2018-06-29       Impact factor: 8.739

Review 10.  Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility.

Authors:  Niels E Skakkebaek; Ewa Rajpert-De Meyts; Germaine M Buck Louis; Jorma Toppari; Anna-Maria Andersson; Michael L Eisenberg; Tina Kold Jensen; Niels Jørgensen; Shanna H Swan; Katherine J Sapra; Søren Ziebe; Lærke Priskorn; Anders Juul
Journal:  Physiol Rev       Date:  2016-01       Impact factor: 37.312
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