BACKGROUND: Infectious complications are frequent in severe acute pancreatitis (SAP) but multinational epidemiologic data are lacking. The aim of the study was to analyze the characteristics of the infectious complications and antimicrobial use in this setting. METHODS: One-day point prevalence study of infection in critically ill patients (Extended Prevalence of Infection in the ICU-II study), performed in 1,265 ICUs in 75 countries. RESULTS: Of the 13,796 patients in the study, 159 were admitted with SAP. One-hundred sixteen (73%) had infections: 31% intra-abdominal, 16% extra-abdominal, and 26% both. Gram-negative bacteria were more prevalent than gram-positive organisms, anaerobes, or fungi. Therapeutically, penicillins and other beta-lactams were used most frequently. Prophylactic antibiotics were administered to 24% of the patients with SAP. CONCLUSIONS: Infections are frequent in patients admitted with SAP; most are intra-abdominal infections. Microbiology is diverse with gram-negative micro-organisms most frequently isolated. Most patients admitted to the ICU for SAP receive antibiotics at some point.
BACKGROUND: Infectious complications are frequent in severe acute pancreatitis (SAP) but multinational epidemiologic data are lacking. The aim of the study was to analyze the characteristics of the infectious complications and antimicrobial use in this setting. METHODS: One-day point prevalence study of infection in critically illpatients (Extended Prevalence of Infection in the ICU-II study), performed in 1,265 ICUs in 75 countries. RESULTS: Of the 13,796 patients in the study, 159 were admitted with SAP. One-hundred sixteen (73%) had infections: 31% intra-abdominal, 16% extra-abdominal, and 26% both. Gram-negative bacteria were more prevalent than gram-positive organisms, anaerobes, or fungi. Therapeutically, penicillins and other beta-lactams were used most frequently. Prophylactic antibiotics were administered to 24% of the patients with SAP. CONCLUSIONS: Infections are frequent in patients admitted with SAP; most are intra-abdominal infections. Microbiology is diverse with gram-negative micro-organisms most frequently isolated. Most patients admitted to the ICU for SAP receive antibiotics at some point.
Authors: Margaret G Keane; Shun Fung Sze; Natascha Cieplik; Sam Murray; Gavin J Johnson; George J Webster; Douglas Thorburn; Stephen P Pereira Journal: Surg Endosc Date: 2015-12-16 Impact factor: 4.584
Authors: Charlotte Garret; Emmanuel Canet; Stéphane Corvec; David Boutoille; Matthieu Péron; Isabelle Archambeaud; Aurélie Le Thuaut; Jean-Baptiste Lascarrou; Frédéric Douane; Marc Lerhun; Nicolas Regenet; Emmanuel Coron; Jean Reignier Journal: Ann Intensive Care Date: 2020-06-15 Impact factor: 6.925