Literature DB >> 24818261

2014 Alzheimer's disease facts and figures.

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Abstract

This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and overall effect on caregivers and society. It also examines the impact of AD on women compared with men. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million are age 65 years or older. By mid-century, fueled in large part by the baby boom generation, the number of people living with AD in the United States is projected to grow by about 9 million. Today, someone in the country develops AD every 67 seconds. By 2050, one new case of AD is expected to develop every 33 seconds, or nearly a million new cases per year, and the total estimated prevalence is expected to be 13.8 million. In 2010, official death certificates recorded 83,494 deaths from AD, making AD the sixth leading cause of death in the United States and the fifth leading cause of death in Americans aged 65 years or older. Between 2000 and 2010, the proportion of deaths resulting from heart disease, stroke, and prostate cancer decreased 16%, 23%, and 8%, respectively, whereas the proportion resulting from AD increased 68%. The actual number of deaths to which AD contributes (or deaths with AD) is likely much larger than the number of deaths from AD recorded on death certificates. In 2014, an estimated 700,000 older Americans will die with AD, and many of them will die from complications caused by AD. In 2013, more than 15 million family members and other unpaid caregivers provided an estimated 17.7 billion hours of care to people with AD and other dementias, a contribution valued at more than $220 billion. Average per-person Medicare payments for services to beneficiaries aged 65 years and older with AD and other dementias are more than two and a half times as great as payments for all beneficiaries without these conditions, and Medicaid payments are 19 times as great. Total payments in 2014 for health care, long-term care, and hospice services for people aged 65 years and older with dementia are expected to be $214 billion. AD takes a stronger toll on women than men. More women than men develop the disease, and women are more likely than men to be informal caregivers for someone with AD or another dementia. As caregiving responsibilities become more time consuming and burdensome or extend for prolonged durations, women assume an even greater share of the caregiving burden. For every man who spends 21 to more than 60 hours per week as a caregiver, there are 2.1 women. For every man who lives with the care recipient and provides around-the-clock care, there are 2.5 women. In addition, for every man who has provided caregiving assistance for more than 5 years, there are 2.3 women.

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Year:  2014        PMID: 24818261     DOI: 10.1016/j.jalz.2014.02.001

Source DB:  PubMed          Journal:  Alzheimers Dement        ISSN: 1552-5260            Impact factor:   21.566


  225 in total

1.  Sevoflurane impairs acquisition learning and memory function in transgenic mice model of Alzheimer's disease by induction of hippocampal neuron apoptosis.

Authors:  Zhen Jia; Lina Geng; Guanglun Xie; Qinjun Chu; Wei Zhang
Journal:  Int J Clin Exp Med       Date:  2015-09-15

Review 2.  Alzheimer's in 3D culture: challenges and perspectives.

Authors:  Carla D'Avanzo; Jenna Aronson; Young Hye Kim; Se Hoon Choi; Rudolph E Tanzi; Doo Yeon Kim
Journal:  Bioessays       Date:  2015-08-07       Impact factor: 4.345

Review 3.  The Proteasome and Oxidative Stress in Alzheimer's Disease.

Authors:  Vicent Bonet-Costa; Laura Corrales-Diaz Pomatto; Kelvin J A Davies
Journal:  Antioxid Redox Signal       Date:  2016-08-25       Impact factor: 8.401

Review 4.  Multimodality Review of Amyloid-related Diseases of the Central Nervous System.

Authors:  Michelle M Miller-Thomas; Adam L Sipe; Tammie L S Benzinger; Jonathan McConathy; Sarah Connolly; Katherine E Schwetye
Journal:  Radiographics       Date:  2016 Jul-Aug       Impact factor: 5.333

5.  Impact of the Baltimore Experience Corps Trial on cortical and hippocampal volumes.

Authors:  Michelle C Carlson; Julie H Kuo; Yi-Fang Chuang; Vijay R Varma; Greg Harris; Marilyn S Albert; Kirk I Erickson; Arthur F Kramer; Jeanine M Parisi; Qian-Li Xue; Eriwn J Tan; Elizabeth K Tanner; Alden L Gross; Teresa E Seeman; Tara L Gruenewald; Sylvia McGill; George W Rebok; Linda P Fried
Journal:  Alzheimers Dement       Date:  2015-03-31       Impact factor: 21.566

6.  The Impact of Dementia Special Care Units on Quality of Care: An Instrumental Variables Analysis.

Authors:  Nina R Joyce; Thomas G McGuire; Stephen J Bartels; Susan L Mitchell; David C Grabowski
Journal:  Health Serv Res       Date:  2018-05-07       Impact factor: 3.402

7.  Pharmacokinetic Properties of a Novel D-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers.

Authors:  Leonie H E Leithold; Nan Jiang; Julia Post; Tamar Ziehm; Elena Schartmann; Janine Kutzsche; N Jon Shah; Jörg Breitkreutz; Karl-Josef Langen; Antje Willuweit; Dieter Willbold
Journal:  Pharm Res       Date:  2015-09-17       Impact factor: 4.200

8.  Use of drugs with anticholinergic properties among nursing home residents with dementia: a national analysis of Medicare beneficiaries from 2007 to 2008.

Authors:  Jacqueline B Palmer; Jennifer S Albrecht; Yujin Park; Sarah Dutcher; Gail B Rattinger; Linda Simoni-Wastila; Loreen D Walker; Ilene H Zuckerman
Journal:  Drugs Aging       Date:  2015-01       Impact factor: 3.923

9.  "Together Make a Visit; Together Make a Plan": Messaging to Adult Children with Concerns about a Parent's Memory Loss.

Authors:  Amy Jordan; Amy Bleakley; Kristin Harkins; Tigist Hailu; Kyle Cassidy; Sara Hachey; Jason Karlawish
Journal:  Health Commun       Date:  2019-02-01

10.  Transgenerational latent early-life associated regulation unites environment and genetics across generations.

Authors:  Debomoy K Lahiri; Bryan Maloney; Baindu L Bayon; Nipun Chopra; Fletcher A White; Nigel H Greig; John I Nurnberger
Journal:  Epigenomics       Date:  2016-03-07       Impact factor: 4.778

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