| Literature DB >> 24817983 |
Stephanie L Holdener1, Lacey Harrington1, Johnny Nguyen1, Pedro Horna2, Elizabeth Sagatys2, Bijal Shah3, Ling Zhang2.
Abstract
Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).Entities:
Keywords: Mantle; lymphoma; therapy; transformation; variant
Mesh:
Substances:
Year: 2014 PMID: 24817983 PMCID: PMC4014267
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN: 1936-2625