Sanna Konstari1, Leena Kaila-Kangas2, Tuija Jääskeläinen2, Markku Heliövaara2, Harri Rissanen2, Jukka Marniemi2, Paul Knekt2, Jari Arokoski3, Jaro Karppinen3. 1. Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. sanna.konstari@student.oulu.fi. 2. Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. 3. Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. Medical Research Center Oulu, Department of Physical and Rehabilitation Medicine, Oulu University Hospital and University of Oulu, Oulu, Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Oulu and Helsinki, Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, Helsinki, Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Department of Physical and Rehabilitation Medicine, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Abstract
OBJECTIVE: The aim of this study was to investigate whether low levels of serum 25-hydroxyvitamin D [25(OH)D] predicts the development of knee or hip OA. METHODS: The cohort consisted of 5274 participants in a national health examination survey who had no knee or hip OA at baseline. Information about the incidence of OA was drawn from the National Health Care Register. During the follow-up of 10 years (50 134 person-years), 127 subjects developed incident, physician-diagnosed OA in the knee and 45 in the hip joint. The information on covariates, including age, sex, education, BMI, work load, leisure time physical activity, smoking history, knee or hip complaint during the past month and previous injuries, was gathered at baseline. Serum 25(OH)D concentrations were determined from baseline serum samples. RESULTS: After adjustment for age and gender, serum 25(OH)D showed statistically significant associations with known risk factors for OA except injuries. In the fully adjusted model, low serum 25(OH)D concentration did not predict increased incidence of knee and hip OA. CONCLUSION: The results do not support the hypothesis that low levels of serum 25(OH)D contribute to the development of knee or hip OA.
OBJECTIVE: The aim of this study was to investigate whether low levels of serum 25-hydroxyvitamin D [25(OH)D] predicts the development of knee or hip OA. METHODS: The cohort consisted of 5274 participants in a national health examination survey who had no knee or hip OA at baseline. Information about the incidence of OA was drawn from the National Health Care Register. During the follow-up of 10 years (50 134 person-years), 127 subjects developed incident, physician-diagnosed OA in the knee and 45 in the hip joint. The information on covariates, including age, sex, education, BMI, work load, leisure time physical activity, smoking history, knee or hip complaint during the past month and previous injuries, was gathered at baseline. Serum 25(OH)D concentrations were determined from baseline serum samples. RESULTS: After adjustment for age and gender, serum 25(OH)D showed statistically significant associations with known risk factors for OA except injuries. In the fully adjusted model, low serum 25(OH)D concentration did not predict increased incidence of knee and hip OA. CONCLUSION: The results do not support the hypothesis that low levels of serum 25(OH)D contribute to the development of knee or hip OA.
Authors: Sanna Konstari; Laura Sares-Jäske; Markku Heliövaara; Harri Rissanen; Paul Knekt; Jari Arokoski; Jouko Sundvall; Jaro Karppinen Journal: PLoS One Date: 2019-03-25 Impact factor: 3.240
Authors: Sanna Konstari; Katri Sääksjärvi; Markku Heliövaara; Harri Rissanen; Paul Knekt; Jari P A Arokoski; Jaro Karppinen Journal: Cartilage Date: 2019-12-21 Impact factor: 3.117
Authors: Vikrant Rai; Nicholas E Dietz; Matthew F Dilisio; Mohamed M Radwan; Devendra K Agrawal Journal: Arthritis Res Ther Date: 2016-09-13 Impact factor: 5.156