Arwa Z Al-Riyami1, Sabah Al-Mahrooqi1, Sumaiya Al-Hinai1, Saif Al-Hosni1, Ali Al-Madhani2, Shahina Daar3. 1. Department of Hematology, Sultan Qaboos University Hospital, Muscat, Oman. 2. Department of Medicine, Sohar Hospital, Muscat, Oman. 3. Department of Hematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: sf.daar@gmail.com.
Abstract
BACKGROUND: Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. STUDY DESIGN AND METHODS: Clinical and blood bank records of 37 TI patients were reviewed. RESULTS: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. CONCLUSION: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.
BACKGROUND:Thalassemia Intermedia (TI) has a wide clinical profile with many patients requiring only occasional transfusions. To prevent alloimmunization, we adopted a policy of issuing phenotype matched red blood cells in 2009. We examined transfusion indications and alloimmunization rate in TI patients. STUDY DESIGN AND METHODS: Clinical and blood bank records of 37 TI patients were reviewed. RESULTS: 23 Patients required transfusion for pregnancy (26), splenectomy (8) and anemia (11). Since 2009, total of 335 units were transfused with only one antibody developing after transfusing a non-phenotype matched unit. CONCLUSION: The commonest indication for blood transfusion was pregnancy. Providing phenotype matched blood has successfully reduced the rate of alloimmunization.
Authors: Arwa Z Al-Riyami; Ali Al-Marhoobi; Saif Al-Hosni; Sabah Al Mahrooqi; Michael Schmidt; Sheila O'Brien; Murtadha Al-Khabori Journal: Oman Med J Date: 2019-11