Literature DB >> 24816171

Dengue virus-infected human dendritic cells reveal hierarchies of naturally expressed novel NS3 CD8 T cell epitopes.

P Piazza1, D Campbell, E Marques, W H Hildebrand, R Buchli, R Mailliard, C R Rinaldo.   

Abstract

Detailed knowledge of dengue virus (DENV) cell-mediated immunity is limited. In this study we characterize CD8(+) T lymphocytes recognizing three novel and two known non-structural protein 3 peptide epitopes in DENV-infected dendritic cells. Three epitopes displayed high conservation (75-100%), compared to the others (0-50%). A hierarchy ranking based on magnitude and polyfunctionality of the antigen-specific response showed that dominant epitopes were both highly conserved and cross-reactive against multiple DENV serotypes. These results are relevant to DENV pathogenesis and vaccine design.
© 2014 British Society for Immunology.

Entities:  

Keywords:  CTL; dengue virus; epitope

Mesh：

Substances：

Year:  2014        PMID： 24816171      PMCID： PMC4137854          DOI： 10.1111/cei.12373

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   5.732


  39 in total

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2.  A systematic bioinformatics approach for selection of epitope-based vaccine targets.

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3.  Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease.

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Journal:  J Virol       Date:  2012-06-27       Impact factor: 5.103

4.  Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells.

Authors:  Daniela Weiskopf; Michael A Angelo; Elzinandes L de Azeredo; John Sidney; Jason A Greenbaum; Anira N Fernando; Anne Broadwater; Ravi V Kolla; Aruna D De Silva; Aravinda M de Silva; Kimberly A Mattia; Benjamin J Doranz; Howard M Grey; Sujan Shresta; Bjoern Peters; Alessandro Sette
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-11       Impact factor: 11.205

5.  Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive.

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6.  Immunogenicity and protective efficacy of a psoralen-inactivated dengue-1 virus vaccine candidate in Aotus nancymaae monkeys.

Authors:  Ryan C Maves; Roger M Castillo Oré; Kevin R Porter; Tadeusz J Kochel
Journal:  Vaccine       Date:  2011-02-17       Impact factor: 3.641

7.  Dengue-specific CD8+ T cells have both protective and pathogenic roles in dengue virus infection.

Authors:  Jing An; De-Shan Zhou; Jun-Lei Zhang; Hatue Morida; Jia-Li Wang; Kotaro Yasui
Journal:  Immunol Lett       Date:  2004-09       Impact factor: 3.685

8.  Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006.

Authors:  Jessica R Fried; Robert V Gibbons; Siripen Kalayanarooj; Stephen J Thomas; Anon Srikiatkhachorn; In-Kyu Yoon; Richard G Jarman; Sharone Green; Alan L Rothman; Derek A T Cummings
Journal:  PLoS Negl Trop Dis       Date:  2010-03-02

9.  NetMHCpan, a method for MHC class I binding prediction beyond humans.

Authors:  Ilka Hoof; Bjoern Peters; John Sidney; Lasse Eggers Pedersen; Alessandro Sette; Ole Lund; Søren Buus; Morten Nielsen
Journal:  Immunogenetics       Date:  2008-11-12       Impact factor: 2.846

10.  NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11.

Authors:  Claus Lundegaard; Kasper Lamberth; Mikkel Harndahl; Søren Buus; Ole Lund; Morten Nielsen
Journal:  Nucleic Acids Res       Date:  2008-05-07       Impact factor: 16.971
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  6 in total

1.  Dengue virus specific dual HLA binding T cell epitopes induce CD8+ T cell responses in seropositive individuals.

Authors:  Joseph D Comber; Aykan Karabudak; Xiaofang Huang; Paolo A Piazza; Ernesto T A Marques; Ramila Philip
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

2.  CD8+ T-cell Responses in Flavivirus-Naive Individuals Following Immunization with a Live-Attenuated Tetravalent Dengue Vaccine Candidate.

Authors:  Haiyan Chu; Sarah L George; Dan T Stinchcomb; Jorge E Osorio; Charalambos D Partidos
Journal:  J Infect Dis       Date:  2015-05-05       Impact factor: 5.226

Review 3.  Identification and selection of immunodominant B and T cell epitopes for dengue multi-epitope-based vaccine.

Authors:  Hui Xuan Lim; Jianhua Lim; Chit Laa Poh
Journal:  Med Microbiol Immunol       Date:  2021-01-30       Impact factor: 3.402

4.  A novel immunization approach for dengue infection based on conserved T cell epitopes formulated in calcium phosphate nanoparticles.

Authors:  Xiaofang Huang; Aykan Karabudak; Joseph D Comber; Mohan Philip; Tulin Morcol; Ramila Philip
Journal:  Hum Vaccin Immunother       Date:  2017-09-21       Impact factor: 3.452

5.  Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas.

Authors:  Alba Grifoni; Michael A Angelo; Benjamin Lopez; Patrick H O'Rourke; John Sidney; Cristhiam Cerpas; Angel Balmaseda; Cassia G T Silveira; Alvino Maestri; Priscilla R Costa; Anna P Durbin; Sean A Diehl; Elizabeth Phillips; Simon Mallal; Aruna D De Silva; Godwin Nchinda; Celine Nkenfou; Matthew H Collins; Aravinda M de Silva; Mei Qiu Lim; Paul A Macary; Filippo Tatullo; Tom Solomon; Vijaya Satchidanandam; Anita Desai; Vasanthapram Ravi; Josefina Coloma; Lance Turtle; Laura Rivino; Esper G Kallas; Bjoern Peters; Eva Harris; Alessandro Sette; Daniela Weiskopf
Journal:  Front Immunol       Date:  2017-10-13       Impact factor: 7.561

Review 6.  Human T Cell Response to Dengue Virus Infection.

Authors:  Yuan Tian; Alba Grifoni; Alessandro Sette; Daniela Weiskopf
Journal:  Front Immunol       Date:  2019-09-04       Impact factor: 7.561
  6 in total

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