OBJECTIVE: To estimate the prevalence of Chagas disease in pregnant women and the risk of congenital transmission of Trypanosoma cruzi infection in Brazil, through a systematic review and meta-analysis. METHODS: We searched electronic databases, grey literature and reference lists of included publications to identify epidemiological studies on the prevalence of Chagas disease in pregnant women and on the congenital transmission rate of T. cruzi infection in Brazil published between January 1980 and June 2013. Pooled estimates and 95% confidence intervals (95% CIs) were calculated using fixed- and random-effects models. RESULTS: Sixteen articles were included - 12 studies on the prevalence of Chagas disease in pregnant women (549,359 pregnant women) and nine on congenital transmission rates (1687 children born to infected mothers). Prevalence of Chagas disease in pregnant women ranged from 0.1% to 8.5%, and congenital transmission rates from 0% to 5.2%. The pooled prevalence of Chagas disease among pregnant women across studies was 1.1% (95% CI: 0.6-2.0); the pooled congenital transmission rate was 1.7% (95% CI: 0.9-3.1). In 2010, 34,629 pregnant women were estimated to be infected with T. cruzi, and 312-1073 children born (mean: 589 cases) with congenital infection. CONCLUSION: Congenital Chagas disease is a neglected public health problem in Brazil. Systematic congenital Chagas disease control programs through routine prenatal screening for T. cruzi should be widely implemented in Brazil's endemic areas, to identify infected pregnant women and newborns at risk of congenital infection.
OBJECTIVE: To estimate the prevalence of Chagas disease in pregnant women and the risk of congenital transmission of Trypanosoma cruzi infection in Brazil, through a systematic review and meta-analysis. METHODS: We searched electronic databases, grey literature and reference lists of included publications to identify epidemiological studies on the prevalence of Chagas disease in pregnant women and on the congenital transmission rate of T. cruzi infection in Brazil published between January 1980 and June 2013. Pooled estimates and 95% confidence intervals (95% CIs) were calculated using fixed- and random-effects models. RESULTS: Sixteen articles were included - 12 studies on the prevalence of Chagas disease in pregnant women (549,359 pregnant women) and nine on congenital transmission rates (1687 children born to infected mothers). Prevalence of Chagas disease in pregnant women ranged from 0.1% to 8.5%, and congenital transmission rates from 0% to 5.2%. The pooled prevalence of Chagas disease among pregnant women across studies was 1.1% (95% CI: 0.6-2.0); the pooled congenital transmission rate was 1.7% (95% CI: 0.9-3.1). In 2010, 34,629 pregnant women were estimated to be infected with T. cruzi, and 312-1073 children born (mean: 589 cases) with congenital infection. CONCLUSION:Congenital Chagas disease is a neglected public health problem in Brazil. Systematic congenital Chagas disease control programs through routine prenatal screening for T. cruzi should be widely implemented in Brazil's endemic areas, to identify infected pregnant women and newborns at risk of congenital infection.
Authors: Alejandro O Luquetti; Suelene Brito do Nascimento Tavares; Liliane da Rocha Siriano; Rozângela Amaral de Oliveira; Dayse Elizabeth Campos; Cicilio Alves de Morais; Enio Chaves de Oliveira Journal: Mem Inst Oswaldo Cruz Date: 2015-03-14 Impact factor: 2.743
Authors: Cynara Carvalho Parente; Fernando S M Bezerra; Plutarco I Parente; Raimundo V Dias-Neto; Samanta C C Xavier; Alberto N Ramos; Filipe A Carvalho-Costa; Marli M Lima Journal: PLoS One Date: 2017-01-19 Impact factor: 3.240
Authors: Raíssa N Brito; David E Gorla; Liléia Diotaiuti; Anália C F Gomes; Rita C M Souza; Fernando Abad-Franch Journal: PLoS Negl Trop Dis Date: 2017-11-16
Authors: Carolina Christianini Mizzaci; Thiago Gonçalves Schroder E Souza; Gabriel Pelegrineti Targueta; Ana Paula Frederico Tótora; Juan Carlos Pachón Mateos; José Carlos Pachon Mateos Journal: Arq Bras Cardiol Date: 2017-06 Impact factor: 2.000
Authors: Francisco Rogerlândio Martins-Melo; Alberto Novaes Ramos; Carlos Henrique Alencar; Jorg Heukelbach Journal: Parasite Epidemiol Control Date: 2016-04-07